Results
Demographic data analysis suggested there was no difference in age and
gender in patients with S. japonicum infection and health control group.
Liver function tests showed that patients with advanced schistosomiasis
had a higher incidence of liver function abnormality and blood lipid
than those with chronic schistosomiasis. Blood routine results reflected
that hemoglobin, red blood cells, platelets, as well as lymphocytes in
the advanced group were significantly less than that in the chronic
group. Furthermore, flow cytometry analysis indicated that the
percentage of CD4+T cells was lower in the advanced
group, but the percentage of CD19+B cells was higher
in the advanced group. In addition, the number of
CD3+T cells,
CD3+CD4+T cells,
CD3+CD8+T cells, and NK cells was
less in the advanced group when compared with those in the chronic
group. In addition, there was a correlation between the decrease in
CD4+ T cells and more severe fibrosis on ultrasound
images.