Figure 1. Integration of information on Bacillus subtilisgenes and proteins in the database SubtiWiki
(http://subtiwiki.uni-goettingen.de).
- Basic information on the highly expressed unknown protein YjlC. The
gene-specific page includes all available information on the protein
as well as graphical interactive elements for the genomic content, the
structure of the protein, the expression of the gene under more than
100 conditions, protein-protein interactions, and regulation of the
gene. Note that the yjlC and ndh genes form an operon,
and the encoded proteins interact physically (see also Table 1)
indicating a functional link between the two proteins.
- The Subti Wiki category for highly expressed understudied
proteins give immediate access to the set of 41 proteins, sorted
according to potential functions (see Table 1).
- The Expression Browser of SubtiWiki allows a direct comparison of the
expression levels of two or more genes (here yjlC andndh ). Similar expression patterns support the idea of a
functional link between two genes/proteins.
Figure 2 . Overview of transporter proteins with unknown
function and amino acids with no known transporter . While some of these
proteins are only expressed during sporulation, others are moderately
expressed under standard growth conditions. For five of twenty
proteinogenic amino acids no transporter responsible for the uptake of
the particular amino acid could be identified. The existence of these
transporters is still guaranteed, as mutants of the synthesis genes for
these five amino acids are viable in complex medium.