Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled studies. |
Table 1. Characteristics of the enrolled
studies. |
Study |
Year |
Country/Number of patients |
Anti-PD-L1 antibody |
Definition of PD-L1 expression in stained cells |
Assessment for IHC
stained cells |
Anatomic location |
Clinicopathological variables
assessment |
Prognostic variables assessment |
Yoshida et al. |
2018 |
Japan/135 |
28-8 Abcam |
TC:M |
Semiquantitative
evaluation(≥50%) |
Only tongue |
Y |
Y |
Adamski et al.
|
2021
|
Poland/109
|
E1L3N,Cell Signaling
|
TC:M
TILs:M&C
|
Percentage of positive cells (TC:>10%;
TILs:>20%)
|
Tongue,floor of the oral cavity,others.
|
Y
|
Y
|
Hirai et al. |
2017 |
Japan/24 |
Abcam |
TC:M |
Percentage of positive
cells(>10%) |
NE |
Y |
N |
Cho et al. |
2011 |
Korea/45 |
Abcam(clone ab82059) |
TC:M &C |
H-score(ranging 0-5,≥3) |
Tongue,floor of mouth, buccal mucosa,
retromolar trigone, hard palate. |
Y |
Y |
Lenouve et al. |
2020 |
Spain/55 |
22C3 clone,Dako |
TC:M |
Tumour
proportion score (TPS)≥5% |
NE |
Y |
Y |
Troeltzsch et al. |
2016 |
Germany/88 |
E1L3N, Cell signaling |
TC: NS |
Semiquantitative evaluation(≥5%) |
Tongue,alveolar process maxilla and
hard palate,soft palate, floor of the mouth, alveolar process mandible. |
Y |
N |
Quan et al. |
2020 |
China/83 |
Clone E1L3N, CST |
IC: NS |
Density of
cells(>10%) |
NE |
Y |
Y |
Togo et al. |
2020 |
Japan/59 |
28-8 Abcam |
IC:M |
Semiquantitative
evaluation(≥10%) |
Tongue,Gingiva,Buccal mucosa,Oral floor,Lip. |
Y |
Y |
Wirsing et al. |
2017 |
Norway/75 |
Clone SP263, Ventana |
TC: M&C |
Percentage of positive cells(>10%) |
NE |
Y |
Y |
Tojyo et al.
|
2019
|
Japan/49
|
790-4905 rabbit monoclonal, Ventana
|
TC:M
TILs:M
|
Percentage of positive cells (TC:≥5%; TILs:≥1%)
|
NE
|
Y
|
Y
|
Geum et al. |
2022 |
Korea/81 |
Abcam |
TC:N&M&C |
H-score(≥ mean
value) |
maxilla,mandible,floor of mouth,Buccal mucosa +etc. |
Y |
Y |
Lin et al. |
2015 |
Taiwan, China/305 |
GTX104763 |
TC:M&C |
Intensity
of staining (ranging 0-3,≥2) |
NE |
Y |
Y |
Akisada et al. |
2020 |
Japan/121 |
E1L3N,Cell Signaling |
TC:NS |
Percentage of positive TCs(≥50%) |
Only tongue |
Y |
Y |
Pena-Cardelles et al. |
2022 |
Spain/65 |
Clone 22C3, Dako |
TC:M |
CPS≥1,TPS≥5%/10% |
Tongue,mouth. |
Y |
Y |
Miranda-Galvis et al. |
2021 |
Brazil/123 |
Abcam(clone 73-10, ab228415) |
TC, IC: M |
TPS≥1%/5%/10% |
NE |
Y |
Y |
Kikuchi et al. |
2019 |
Japan/103 |
Clone 28-8; Abcam |
TC:M |
CPS≥1 |
NE |
N |
Y |
Wang et al. |
2019 |
China/36 |
Abcam, ab213524 |
TC:M |
H-score(≥4) |
NE |
N |
Y |
de Vicente et al. |
2018 |
Spain/125 |
Clone E1L3N, clone 22C3, Dako |
TC:NS |
Percentage of positive TCs(≥10%) |
Tongue,floor of the
mouth,gum,buccal,retromolar,palate. |
Y |
Y |
Kouketsu et al. |
2017 |
Japan/106 |
Clone SP142,Ventana |
TC:M&C |
H-score(≥1) |
Tongue,Upper gingiva, Lower gingiva, Hard palate,Buccal
mucosa, Floor of mouth,Lower lip. |
Y |
Y |
Straub et al. |
2016 |
Germany/80 |
Clone E1L3N |
TC:M |
Percentage of
positive cells (≥5%) |
NE |
Y |
Y |
Chen T-C et al. |
2015 |
Taiwan, China/218 |
Proteintech Group |
TC:M |
Percentage of positive cells (≥5%) |
NE |
N |
Y |
Takamaru et al. |
2022 |
Japan/169 |
Clone SP142,Ventana |
TC:M |
Percentage of positive TCs(>1%) |
NE |
Y |
Y |
Klein et al. |
2021 |
Germany/58 |
22C3 clone,Dako |
TC:M |
Intensity of
staining (ranging 0-3,≥2) |
lip cancer |
Y |
Y |
Satgunaseelan et al. |
2016 |
Australia/217 |
E1L3N-XP-Rb mAb |
TC: M |
Percentage of positive cells (≥5%) |
Tongue,floor of mouth,
gingiva,buccal. |
Y |
Y |
Takahashi et al. |
2019 |
Japan/77 |
E1L3N, Cell signaling |
TC:M |
Semiquantitative evaluation(≥10%) |
NE |
Y |
Y |
de Sa et al. |
2021 |
Brazil/48 |
NS |
TC:M |
Intensity of
staining(>0%) |
Only tongue |
N |
Y |
Wilms et al. |
2020 |
Sweden/101 |
Clone SP263, Ventana |
TC,IC: M&C |
H-score(ranging0-18,≥6) |
Only tongue |
Y |
Y |
Huang et al. |
2020 |
China/152 |
Abcam,ab52587 |
TC,IC: M&C |
H-score(≥2) |
Only tongue |
Y |
Y |
Hanna et al. |
2017 |
USA/81 |
Clone 9A11 |
TC:M&C |
Percentage of
positive cells (≥10%) |
NE |
N |
Y |
Maruse et al. |
2018 |
Japan/97 |
Clone E1L3N, Cell Signaling |
TC:M&C |
Percentage of positive cells (≥5%) |
NE |
N |
Y |
Ahn et al. |
2017 |
Korea/68 |
Clone ab153991, Abcam |
TC:M&C |
Semiquantitative evaluation(≥10%) |
NE |
Y |
Y |
Balermpas et al. |
2017 |
Germany/41 |
Clone E1L3N |
TC:NS |
Percentage
of positive cells(>5%) |
NE |
N |
Y |
Foy et al. |
2017 |
France/44 |
Clones SP142, 28.8 |
TC:NS |
Percentage
of positivecells(≥1,≥5,and≥10%) |
NE |
Y |
N |
Kogashiwa et al. |
2017 |
Japan/84 |
Clones SP142 |
TC:M&C |
Percentage
of positive cells(>5%) |
NE |
Y |
Y |
Mattox et al. |
2017 |
USA/53 |
Clone 5H1 |
TC: M |
Percentage of
positive TCs and/or TILs (> 1%) |
Only tongue |
Y |
Y |
Moratin et al. |
2019 |
Germany/175 |
Cell signaling |
TC:NS |
H-score(≥4) |
NE |
Y |
Y |
Naruse et al. |
2019 |
Japan/121 |
Abcam(clone ab156361) |
TC:C&N |
Percentage of positive TCs(>5%) |
Only tongue |
Y |
Y |
Oliveira-Costa et al. |
2015 |
Brazil/96 |
Abcam(clone ab28753) |
TC:M,
C |
Percentage of positive cells (>5%) |
NE |
Y |
Y |
Schneider et al. |
2018 |
Austria/36 |
Clone 5H1 |
TC:M |
Percentage of
positive cells (>5%) |
Only tongue |
N |
Y |
Tsai et al. |
2019 |
Taiwan, China/173 |
NS |
NS |
H-score |
NE |
N |
Y |
Udeabor et al. |
2018 |
Nigeria/20 |
28-8 Abcam |
TC:NS |
H-score(≥0) |
NE |
Y |
N |
Manikhas et al. |
2018 |
Russia/82 |
clone BCDdx1020 by ICH |
TC:NS |
Percentage of positive cells (TC:≥1%;≥5%) |
NE |
N |
Y |
Ahmadi et al. |
2019 |
Australia/255 |
E1L3N-XP-Rb mAb |
TC:M |
Percentage of positive TCs (≥1%) |
NE |
Y |
Y |
Subramaniam et al. |
2021 |
India/64 |
NS |
TC,TILs:M&C |
Intensity of
staining (ranging 0-3,≥1) |
Tongue and buccal mucosa. |
Y |
Y |
Chen X-J et al. |
2019 |
China/41 |
clone SP142, abcam |
TC:C |
Percentage of positive cells (≥5%) |
Only tongue |
N |
Y |
Zhao et al. |
2019 |
China/46 |
ab205921,abcam |
TC:M&C |
Percentage of
positive TCs (≥50%) |
Only tongue |
Y |
N |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |
Abbreviations: TC: tumor cell; IC: immune cell; IHC:
immunohistochemistry; M: membranous; C: cytoplasmic; N:nuclei; NS:not
stated; NE: not examined. H:defined as staining intensity × the
percentage of staining cells; CPS: combined positive score; TPS: tumour
proportion score. |