Background and Purpose
Vancomycin is one of the most common antibiotics administered in the
hospital setting, yet acute kidney injury is a major limiting factor.
Common combinations of antibiotics with vancomycin have been reported to
worsen and improve vancomycin-induced kidney injury. We aimed to study
the impact of flucloxacillin and imipenem-cilastatin on kidney injury
when combined with vancomycin in our translational rat model.