Affiliations:
1 Midwestern University- Downers Grove Campus,
Department of Pharmacy Practice, Downers Grove, IL, USA;
2 Midwestern University- Downers Grove Campus,
Pharmacometrics Center of Excellence, Downers Grove, IL, USA;
3 Northwestern Memorial Hospital, Department of
Pharmacy, Chicago, IL, USA;
4Victorian Infectious Diseases Service, The Royal
Melbourne Hospital, at the Peter Doherty Institute for Infection and
Immunity, Melbourne, Australia
5Department of Infectious Diseases, The University of
Melbourne at the Peter Doherty Institute for Infection and Immunity,
Melbourne, Australia
6Hunter Medical Research Institute, University of
Newcastle, Newcastle, NSW, Australia
7 Midwestern University- Downers Grove Campus,
Department of Pharmacology, Downers Grove, IL, USA;
8 Present affiliation: Division of Pharmacometrics,
Office of Clinical Pharmacology, Office of Translational Sciences,
United States Food and Drug Administration, Silver Spring, MD, USA
9 Present affiliation: Cellular and Molecular
Pharmacology, Foundational Sciences and Humanities, Chicago Medical
School, Rosalind Franklin University of Medicine and Science, North
Chicago, IL, USA.
* Corresponding author and reprint requests: Marc H. Scheetz,
PharmD, MSc; Professor of Pharmacy Practice and Pharmacology; Midwestern
University; 555 31st St., Downers Grove, IL 60515,
Phone: 630-515-6116; Fax: 630-515-6958; Email:
mschee@midwestern.edu
Word count: 1880 Abstract word count (250 max): 251
ACKNOWLEDGEMENTS
The present study was funded in part by a MWU Intramural Grant (MS).
Control and vancomycin alone animals were carried forward (as described
in methods) from studies supported in part by the National Institute of
Allergy and Infectious Diseases under award number R21-AI149026 (authors
MS, GP). The content is solely the responsibility of the authors and
does not necessarily represent the official views of the National
Institutes of Health. Disclaimer from author J. Liu: The opinions
expressed in this article are those of the author and should not be
interpreted as the position of the United States Food and Drug
Administration.
The authors thank Kristi Kozierowski for providing the flucloxacillin .
The authors thank the staff of the MWU Vivarium and the Core Facility.
While this study followed our previously published approaches, the
research and analysis plan for this manuscript was not preregistered.
CONFLICT OF INTEREST STATEMENT
MS reports ongoing research contracts with Nevakar and SuperTrans
Medical as well as having filed patent US10688195B2. All other authors
have no other related conflicts of interest to declare.
Data availability statement: Data available on request from the
authors: The data that support the findings of this study are available
from the corresponding author upon reasonable request. Data sharing will
be subject to standard Data Use Agreements from Midwestern University.