Key Results
Urinary output increased every study day for vancomycin+flucloxacillin;
whereas in the vancomycin group it was elevated after the first dose
only. In the vancomycin+flucloxacillin group, urinary KIM-1/24h
increased on all days compared to vancomycin. In the
vancomycin+imipenem-cilastatin group, urinary KIM-1/24h was decreased on
days 1 and 2 compared to vancomycin. Similar trends were observed for
clusterin. More vancomycin accumulated in the kidney with
vancomycin+flucloxacillin compared to vancomycin and
vancomycin+imipenem-cilastatin. The accumulation of vancomycin in the
kidney tissue correlated with increasing urinary KIM-1 (4-parameter Hill
Slope, R2=0.7985).