5.1 Endometriosis
Endometriosis (EMs) is, a chronic inflammatory disorder characterized mainly affecting pelvic tissues, including ovaries and fallopian tubes.37, 38 It affects 11% of women worldwide who are of reproductive age, with up to 50% of them reporting pelvic pain or infertility.37-41
Based on previous research, the microenvironment in pelvic cavity of endometriosis patients contains excessive free iron and ROS, which is more conducive to the occurrence of ferroptosis 42. Ferroptosis is an important contributor to the pathogenesis of endometriosis. First, endometrial cells can survive and develop endometriotic lesions during retrograde menstruation due to the resistance to ferroptosis, the pathophysiological alterations that follow in EMs are largely due to ferroptosis.