Ferroptosis
|
Cell swelling, plasma membrane rupture, smaller mitochondria, increased
mitochondrial, membrane densities
|
Iron accumulation, lipid peroxidation increase, Antioxidant defense
decrease
|
GPX4,
GSH,
ACSL4,
TFRC,
PTGS2, CHAC1
|
EMs, PCOS,
POI, GMD, PE, OC
|
2, 4, 12
|
Apoptosis
|
nuclear fragment, chromatin agglutination, cell membrane rupture
|
Activation of caspase proteins, DNA fragmentation
Cytochrome C release
|
caspase-8
caspase-3
|
POI, PE
PCOS
|
20-23
|
Necroptosis
|
Cell swelling, plasma-membrane rupture
|
ATP deplete, Activate inflammatory reaction
|
Phospho-MLKL, phospho-RIP, RIP, phospho-RIP3, RIP3
|
PE, OC,
FGR
|
27-31
|
Pyroptosis
|
chromatin condensation, intact nuclei, cellular swelling, and plasma
membrane rupture
|
caspase-dependent,
|
caspase-1,IL1β , IL18,
Gasdermin D
|
PE, PCOS, POI
|
32-35
|