5.1 Endometriosis
Endometriosis (EMs) is, a chronic inflammatory disorder characterized
mainly affecting pelvic tissues, including ovaries and fallopian
tubes.37, 38 It affects 11% of women worldwide who
are of reproductive age, with up to 50% of them reporting pelvic pain
or infertility.37-41
Based on previous research, the microenvironment in pelvic cavity of
endometriosis patients contains excessive free iron and ROS, which is
more conducive to the occurrence of ferroptosis 42.
Ferroptosis is an important contributor to the pathogenesis of
endometriosis. First, endometrial cells can survive and develop
endometriotic lesions during retrograde menstruation due to the
resistance to ferroptosis, the pathophysiological alterations that
follow in EMs are largely due to ferroptosis.