Diseases Drugs Mechanism Effects References
EMs Vitamin E Inhibit the peroxidation chain and lipoxygenase expression Inhibiting ferroptosis and improve the fertility 61, 112, 113
deferoxamine mesylate Decrease iron level
PCOS
Ferrostatin‑1
decrease ROS, MDA and LDH improve GPX4
Reduce ferroptosis and protect ovarian granulosa cells
71-73
N-acetylcysteine Increase GPX4 Attenuate gravid uterine and placental ferroptosis, reduce fetal loss
Cryptotanshinone inhibit MMP and NF-κB, activate MAPK/ERK signaling Regulate ferroptosis and protects against PCOS-induced damage
PE Nrf2,DJ-1 inhibit the levels of GSH, MDA, ROSs, and Fe2+ and improve the SLC7A11, GPX4, and FPN1, Inhibit ferroptosis and relieve hypoxia 95, 96
GMD Adiponectin restoration of CPT-1 activity to reduce oxidation stress ameliorate placental injury 80
OC erastin inhibit System Xc- and result in depletion of GSH inhibit tumor growth 109