EMs |
Vitamin E |
Inhibit the peroxidation chain and lipoxygenase
expression |
Inhibiting ferroptosis and improve the fertility |
61, 112, 113 |
|
deferoxamine mesylate |
Decrease iron level |
|
|
PCOS
|
Ferrostatin‑1
|
decrease ROS, MDA and LDH
improve GPX4
|
Reduce ferroptosis and protect ovarian granulosa cells
|
71-73
|
|
N-acetylcysteine |
Increase GPX4 |
Attenuate gravid uterine and
placental ferroptosis, reduce fetal loss |
|
|
Cryptotanshinone |
inhibit MMP and NF-κB, activate MAPK/ERK signaling |
Regulate ferroptosis and protects against PCOS-induced damage |
|
PE |
Nrf2,DJ-1 |
inhibit the levels of GSH, MDA, ROSs, and
Fe2+ and improve the SLC7A11, GPX4, and FPN1, |
Inhibit ferroptosis and relieve hypoxia |
95,
96 |
GMD |
Adiponectin |
restoration of CPT-1 activity to reduce oxidation
stress |
ameliorate placental injury |
80 |
OC |
erastin |
inhibit System Xc- and result in depletion of GSH |
inhibit tumor growth |
109 |