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\begin{document}

\title{Establishing a local centre of excellence for research and training in
pharmacometrics: Lessons from the Pharmacometrics Africa -Uganda chapter}



\author[1]{Letisha  Najjemba }%
\author[2]{Aida Kawuma}%
\author[3]{Francis Williams}%
\author[4]{Bonniface  Obura}%
\author[1]{Christine Sekaggya-Wiltshire}%
\author[1]{Joseph Arinaitwe}%
\author[1]{Ruth Kikonyogo}%
\author[5]{Jackson Mukonzo}%
\author[6]{Goonaseelan Pillai}%
\author[7]{Catriona Waitt}%
\affil[1]{Makerere University College of Health Sciences}%
\affil[2]{University of Cape Town}%
\affil[3]{Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala (Uganda)}%
\affil[4]{Lira University}%
\affil[5]{Karolinska Institutet}%
\affil[6]{CP Plus Associates}%
\affil[7]{University of Liverpool Institute of Translational Medicine}%


\vspace{-1em}



  
  \date{June 10, 2024}


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\begin{abstract}
Pharmacometrics Africa is a not-for-profit company registered in South
Africa as an established platform for interested groups to establish and
run open-access quantitative clinical pharmacology educational programs
in partnership with local research organizations and academic groups.
Pharmacometric research and clinical application is pivotal in
characterising and optimising treatments, especially for complex or
understudied populations. The application of pharmacometrics in drug
development during recent years has led to an increase in the adoption
of this technique in many drug companies and increased the demand for
skilled pharmacometricians globally. Stringent regulatory authorities
such as the US-FDA and EMA have increasingly populated their review
groups with these scientists, further increasing the demand for the
expertise and, more importantly, evidencing the impact and importance of
pharmacometrics within the drug development cycle. Creative solutions
are required to provide adequate training resources for the future.
Pharmacometrics is nascent in Africa. Here, we report on establishing
the Ugandan Chapter of Pharmacometrics Africa. This aims to transfer
primary training responsibility to local institutions and faculty for
sustainability and to build upon regional strengths in pharmacometrics.
Creating a local centre of excellence will help attract both regional
and international collaborations on quantitative clinical pharmacology.
We summarize our experience, key lessons learnt and future perspectives.%
\end{abstract}%



\sloppy


\textbf{Establishing a local centre of excellence for research and
training in pharmacometrics: Lessons from the Pharmacometrics Africa
-Uganda chapter}

\emph{Authors:} \textbf{Letisha Najjemba\textsuperscript{1}, Aida
Nakayiwa Kawuma\textsuperscript{1}, Francis Williams
Ojara\textsuperscript{1,5}, Bonniface
Obura\textsuperscript{3,7}Christine Sekaggya\textsuperscript{1,2},
Walter Arinaitwe\textsuperscript{1}, Ruth Kikonyogo\textsuperscript{1},
Jackson Mukonzo\textsuperscript{8}} , \textbf{Goonaseelan (Colin)
Pillai\textsuperscript{3,6}, Catriona Waitt\textsuperscript{1,4}}

\begin{enumerate}
\tightlist
\item
  Infectious Diseases Institute, College of Health Sciences, Makerere
  University, Kampala Uganda
\item
  Department of Medicine, College of Health Sciences, Makerere
  University, Kampala, Uganda
\item
  CP+ Associates GmbH, Basel, Switzerland
\item
  Department of Pharmacology and Therapeutics, University of Liverpool,
  United Kingdom
\item
  Department of Pharmacology and Therapeutics, Gulu University, Uganda
\item
  Division of Clinical Pharmacology, University of Cape Town, Cape Town,
  South Africa
\item
  Department of Pharmacology and Therapeutics, Lira University, Uganda
\item
  Department of Pharmacology and Therapeutics, College of Health
  Sciences, Makerere University, Kampala, Uganda
\end{enumerate}

This is a review article for What can modelling do for
you?\emph{Keywords: Pharmacometrics, Clinical Pharmacology, Ugandan
chapter, pharmacokinetics}

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\verb`Acknowledgment.docx`  available at \url{https://authorea.com/users/573202/articles/617629-establishing-a-local-centre-of-excellence-for-research-and-training-in-pharmacometrics-lessons-from-the-pharmacometrics-africa-uganda-chapter}

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\verb`Table 2.docx`  available at \url{https://authorea.com/users/573202/articles/617629-establishing-a-local-centre-of-excellence-for-research-and-training-in-pharmacometrics-lessons-from-the-pharmacometrics-africa-uganda-chapter}

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