5 Conclusion
In a word, clinical suspicion of AIFRS should be alert in the
immunocompromised patient presenting with new-onset, rapidly progressive
sinusitis with facial-cranio-orbital spread. A multidisciplinary
approach consisting of antifungal therapy, surgical debridement,
immunodeficiency reversal, and supportive treatment
were essential to improve the control. We need more focus on
comprehensive assessment, an extended debridement such as maxillectomy
and orbital exenteration should be considered on a case-by-case basis.
The outcome of AIFRS with facial-cranio-orbital involved was usually
fatal which mainly defined by the underlying disease.