Author contributions
Y.G.F. performed most of the experiments and wrote the manuscript; L.X.Z. and R.L.G. contributed to experiments; Z.Q.P. and H. R. generated and validated the mouse model; D.L.H. and Y.H.Z. contributed to the discussion; C. G. and Z.Y.W. designed the experiments and edited the manuscript. All authors have read and approved the final manuscript.