The origin of widespread volcanism far from plate boundaries and mantle plumes remains a fundamental unsolved question. An example of this puzzle is the Anatolian region, where abundant intraplate volcanism has occurred since 10 Ma, but a nearby underlying plume structure in the deep mantle is lacking. We employed a combination of seismic and geochemical data to link intraplate volcanism in Anatolia to a trail of magmatic centers leading back to East Africa and its mantle plume, consistent with northward asthenospheric transport of over ~2500 km distance. Joint modeling of seismic imaging and petrological data indicates that the east Anatolian mantle potential temperature is higher than the ambient mantle (~1420C). Based on multiple seismic tomography models, the Anatolian upper mantle is likely connected to East Africa by an asthenospheric channel with low seismic velocities. Along the channel, isotopic signatures among volcanoes are consistent with a common mantle source, and petrological data demonstrate similar elevated mantle temperatures, consistent with little cooling in the channel during the long-distance transport. Horizontal asthenospheric pressure gradients originating from mantle plume upwelling beneath East Africa provide a mechanism for high lateral transport rates that match the relatively constant mantle potential temperatures along the channel. Rapid long-distance asthenospheric flow helps explain the widespread occurrence of global intraplate magmatism in regions far from deeply-rooted mantle plumes throughout Earth history.