Surface water is the most readily accessible water resource and provides an array of ecosystem services, but is stressed by changes in climate, land cover, and population size. Understanding drivers of surface water dynamics in space and time is key to better managing our water resources. However, few studies estimating changes in surface water account for climate and anthropogenic drivers both independently and together. We used 19 years (2000-2018) of the newly developed Dynamic Surface Water Extent Landsat Science Product in concert with time series of precipitation, temperature, land cover, and population size to statistically model maximum seasonal percent surface water area as a function of climate and anthropogenic drivers in the Southeastern U.S. We fitted three statistical models (linear mixed effects, random forests, and mixed effects random forests) and three groups of explanatory variables (climate, anthropogenic, and their combination) to assess the accuracy of estimating percent surface water area at the watershed scale with different drivers. We found that anthropogenic drivers accounted for approximately 37% more of the variance in the percent surface water area than the climate variables. The combination of variables in the mixed effects random forest model produced the smallest mean percent errors (mean -0.17%) and the highest explained variance (R² 0.99). Our results indicate that anthropogenic drivers have greater influence when estimating percent surface water area than climate drivers, suggesting that water management practices and land use policies can be highly effective tools in controlling surface water variations in the Southeastern U.S.