Amphibole is a common hydrous mineral in mantle rocks. To better understand the processes leading to the formation of amphibole-bearing peridotites and pyroxenites in mantle rocks, we have undertaken an experimental study reacting lherzolite with hydrous basaltic melts in Au-Pd capsules using the reaction couple method. Two melts were examined, a basaltic andesite and a basalt, each containing 4 wt% of water. The experiments were run at 1200°C and 1 GPa for 3 or 12 h, and then cooled to 880°C and 0.8 GPa over 49 h. The reaction at 1200°C and 1 GPa produced a melt-bearing orthopyroxenite-dunite sequence. The cooling stimulates crystallization of orthopyroxene, clinopyroxene, amphibole, and plagioclase, leading to the formation of an amphibole-bearing gabbronorite–orthopyroxenite–peridotite sequence. Compositional variations of minerals in the experiments are controlled by temperature, pressure, and reacting melt composition. Texture, mineralogy, and mineral compositional variation trends obtained from the experiments are similar to those from mantle xenoliths and peridotite massif from the field including amphibole-bearing peridotites and amphibole-bearing pyroxenite and amphibolite that are spatially associated with peridotites, underscoring the importance of hydrous melt-peridotite reaction in the formation of these amphibole-bearing rocks in the upper mantle. Amphiboles in some field samples have distinct textual and mineralogical features and their compositional variation trends are different from that defined by the melt-peridotite reaction experiments. These amphiboles are either crystallized from the host magma that entrained the xenoliths or product of hydrothermal alterations at shallow depths.