A new seismic velocity model for the south Central Andes is derived from full waveform inversion, covering the Pampean flat and adjacent Payenia steep subduction segments. Strong focused crustal low-velocity anomalies indicate partial melts in the Payenia segment along the volcanic arc, whereas weaker low-velocity anomalies covering a wide zone in Pampean possibly indicates remnant melts in the past. Thinning and tearing of the flat Nazca slab below the Pampean is inferred by gaps in the high-velocity slab along the inland projection of the Juan-Fernandez-Ridge. A high-velocity anomaly in the upper mantle below the flat slab is interpreted as a relic Nazca slab segment, which indicates an earlier slab break-off during the flattening process, triggered by the buoyancy of the Juan-Fernandez-Ridge. In Payenia, large-scale low-velocity anomalies atop and below the re-steepened Nazca slab are associated with the re-opening of the mantle wedge and sub-slab asthenospheric flow, respectively.