Ultrasonographic anomaly Ultrasonographic anomaly N Aneuploidy (%) pCNV
N (%) P OR (95% CI)
1 cardiovascular system 3,620 (27.19%) 207 (5.72%) 256 (7.07%) < 0.0001 3.85 [3.38,4.37]
genitourinary system 1,743 (13.09%) 19 (1.09%) 73 (4.19%) < 0.0001 2.21 [1.72,2.80]
abnormal amniotic fluid 1,057 (7.94%) 24 (2.27%) 35 (3.31%) 0.051 1.73 [1.20,2.43]
central nervous system 980 (7.36%) 31 (3.16%) 65 (6.63%) < 0.0001 3.59 [2.75,4.62]
fetal growth restriction 856 (6.43%) 16 (1.87%) 55 (6.43%) < 0.0001 3.47 [2.59,4.56]
gastrointestinal system 820 (6.16%) 30 (3.66%) 32 (3.90%) 0.0046 2.05 [1.39,2.92]
skeletal system 774 (5.81%) 28 (3.62%) 52 (6.72%) < 0.0001 3.64 [2.69,4.83]
facial system 616 (4.63%) 14 (2.27%) 30 (4.87%) < 0.0001 2.59 [1.73,3.73]
respiratory system 497 (3.73%) 9 (1.81%) 30 (6.04%) < 0.0001 3.25 [2.17,4.70]
cystic hygroma 416 (3.13%) 103 (24.76%) 20 (4.81%) 0.0036 2.55 [1.54,4.00]
fetal hydrops 264 (1.98%) 92 (34.85%) 10 (3.79%) 0.62 1.99 [0.94,3.72]
abdominal wall defect 175 (1.31%) 24 (13.71%) 13 (7.43%) 0.00066 4.06 [2.11,7.14]
Total 11,818 (88.78%) 597 (5.05%) 671 (5.68%) < 0.0001 3.04 [2.81,3.29]
2 2 1,220 (9.16%) 202 (16.56%) 119 (9.75%) < 0.0001 5.46 [4.49,6.61]
≥ 3 ≥ 3 274 (2.06%) 79 (28.83%) 41 (14.96%) < 0.0001 8.89 [6.22,12.44]