Pharmacokinetic parameters

The mean pharmacokinetic parameters estimated for Reference product (R) and Test product (T) are depicted in Table 1. The geometric least squares mean of Test Formulation (T) and Reference Formulation (R), its ratio (T/R)%, intra-subject variability, 90% confidence intervals the Geometric least square mean ratio (T/R) and power obtained from the analysis of ln-transformed parameters AUC0-t and AUC0-∞ are summarized in Table 2 The GMR (90% CI) of the AUClast between the test and the reference formulations was 1.46 (1.37–1.55). Thus, the test product (6 Mercaptopurine 10 mg/mL (at a dose of 5 mL = 50 mg) did not meet the bioequivalence criteria as the bioavailability of suspension was 46% higher compared to the tablet.