RESULTS
The 6MP PFOS had 47% higher bioavailability compared to the reference
product. Simulations using a two-compartmental PopPK model with
dissolution and transit compartments showed that 40 mg of PFOS was found
to be equivalent to the 50mg tablets. The simulated 6TGN concentrations
in virtual paediatric patients were between 114 and 703.6
pmol/8x108 RBCs, which was within the range of values
reported in paediatric ALL studies.