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\title{}



\author[1]{Zhenglin Chang}%
\author[2]{Lei Min}%
\author[1]{Zhangkai Jason Cheng}%
\author[1]{Jiale Zhang}%
\author[1]{Xiaocong Pan}%
\author[1]{Zilin Zeng}%
\author[1]{Baoqing Sun}%
\affil[1]{First Affiliated Hospital of Guangzhou Medical University}%
\affil[2]{Guangdong Provincial Key Laboratory of Urology}%


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  \date{May 20, 2024}


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\begin{abstract}
\textbf{BACKGROUND:} Increasing numbers of research have revealed an
etiological association between peripheral blood markers and allergy.
Nevertheless, whether these associations are causal and whether they
vary among different allergic diseases and ethnicities remain unclear.
\textbf{METHODS:} 32 peripheral biomarkers with consistent definition
were collected from three nationwide biobanks (UK Biobank, FinnGen, and
BioBank Japan). Summary-level data for asthma (n=774,328), dermatitis
(n=880,733), and allergic rhinitis (n=893,300) were obtained from these
biobanks. Mendelian randomization (MR) analyses and meta-analyses were
applied to explore the generalizability and heterogeneity of causal
effects among different allergic diseases and ethnicities. The clinical
data (n=9,877) in China and US were collected to verify peripheral
markers affecting allergy. \textbf{RESULTS:} \textbf{ONCLUSIONS:} Our
results support the causal effects of 22 blood heritable factors on
allergic diseases, providing novel insights into the comprehensive
assessment of allergic risks and the design of universal and
personalized interventions.%
\end{abstract}%



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