Conclusion
Overall, we demonstrated that cognitive deficits in drug-resistant
temporal lobe epilepsy may lead to slowing of general EEG activity, loss
of efficiency in gamma band connectivity, and increased Aβ and p-Tau
expression. The EEG and pathological changes in these patients indicated
that high frequency may be an evaluation marker and a potential
therapeutic target for cognitive dysfunction.
Conflict of interests: None of the authors have potential
conflicts of interest to be disclosed.
Ethics statement: The studies involving human participants were
reviewed and approved by The Ethics Committee of Peking Union Medical
College Hospital (No. JS3511). The patients/participants provided their
written informed consent to participate in this study.