Figure legends
Figure 1. Small world index (SWI) trends in drug-resistant TLE and control groups. SWI in the AC group decreased in alpha frequency compared to that in the NC group and controls. The SWI increased in beta frequency in both TLE groups, then declined in gamma frequency in AC group. TLE: temporal lobe epilepsy; NC: normal cognition; AC: abnormal cognition.
Figure 2. Association between cognitive scales and small world index (SWI) by Spearman’s correlations. (A-D) SWI in alpha and gamma frequency bands (50-70Hz) showed positive correlation with intelligence quotient and memory quotient after FDR correction.
Figure 3. Frequency spectral analysis in drug-resistant temporal lobe epilepsy (TLE) patients. (A) & (B) Across-channel grand average of Power spectral density (PSD) showed increased delta power and decreased alpha power in drug-resistant TLE groups, compared to controls. (C) & (D) Increased delta power in TLE groups are mainly over the anterior regions. For gamma frequencies, the relative PSD over the central, frontal, and temporal areas was lower in the TLE groups than in the controls.
Figure 4. Amyloid-β (Aβ) and phosphorated-Tau (p-Tau) immunofluorescence in hippocampus of drug-resistant TLE. (A)Different Aβ expression between NC and AC groups is observed, with similar Neun expression. (B) The p-Tau deposition is more severe in AC group, compared with NC group, while the expression of MAP2 is similar in two groups. (C) Quantitative analysis showed substantial differences between NC and AC groups in Aβ and p-Tau expression. NC: normal cognition; AC: abnormal cognition.