Limitations
The present study had limitations. First, the WIS scores were lacking in
the control group, and would enable more robust conclusions from
comparisons between controls and drug-resistant TLE patients.
Nonetheless, a detailed medical history, especially concerning
neurological diseases, was reviewed for healthy controls. Additionally,
all controls passed the primary cognition test with calculation and
memory abilities. Second, a larger sample size for the pathological
analysis will further validate these data. Moreover, evaluating
pathological factors directly reflecting the cause of impaired
efficiency of brain connectivity, such as synapsis and myelination
status may lead to more robust conclusions.