Conclusion
Overall, we demonstrated that cognitive deficits in drug-resistant temporal lobe epilepsy may lead to slowing of general EEG activity, loss of efficiency in gamma band connectivity, and increased Aβ and p-Tau expression. The EEG and pathological changes in these patients indicated that high frequency may be an evaluation marker and a potential therapeutic target for cognitive dysfunction.
Conflict of interests: None of the authors have potential conflicts of interest to be disclosed.
Ethics statement: The studies involving human participants were reviewed and approved by The Ethics Committee of Peking Union Medical College Hospital (No. JS3511). The patients/participants provided their written informed consent to participate in this study.