Pathology in hippocampus of drug-resistant TLE
Hippocampal tissues were available in seven patients with drug-resistant
TLE, four in the AC group, and three in the NC group. The mean disease
course was 13 years from seizure onset (5–23 years) in the NC group and
17 years (17–23 years) in the AC group. There were no significant
differences in disease course, sex, or age. All patients underwent MMSE
(Table 2). The mean MMSE score was 28 (28–29) in the AC group and 20
(17–23) in the NC group. Immunofluorescence revealed Aβ and p-tau
deposits in both the NC and AC groups (Figure 4A and B). Three sampled
regions (×200) were randomly selected from the hippocampus of each
patient. The percentage of each sampled area with positive Aβ and p-Tau
immunofluorescence was calculated using a quantitative analysis (Table
2). The mean percentage of Aβ in the sampled regions was 0.13%
(0.03%–0.26%) in the NC group and 0.26% (0.01%–0.67%) in the AC
group. The mean p-Tau load was 0.61% (0.25%–1.25%) in the NC group
and 1.20% (0.58%–2.33%) in the AC group. As shown in Table 2 and
Figure
4C,
there was a significant difference in the severity of Aβ and p-Tau load
between the NC and AC groups (Aβ: p NC-AC = 0.034;
p-Tau: p NC-AC = 0.012).