Limitations
The present study had limitations. First, the WIS scores were lacking in the control group, and would enable more robust conclusions from comparisons between controls and drug-resistant TLE patients. Nonetheless, a detailed medical history, especially concerning neurological diseases, was reviewed for healthy controls. Additionally, all controls passed the primary cognition test with calculation and memory abilities. Second, a larger sample size for the pathological analysis will further validate these data. Moreover, evaluating pathological factors directly reflecting the cause of impaired efficiency of brain connectivity, such as synapsis and myelination status may lead to more robust conclusions.