Figure legends
Figure 1. Small world index (SWI) trends in
drug-resistant TLE and control groups. SWI in the AC group decreased in
alpha frequency compared to that in the NC group and controls. The SWI
increased in beta frequency in both TLE groups, then declined in gamma
frequency in AC group. TLE: temporal lobe epilepsy; NC: normal
cognition; AC: abnormal cognition.
Figure 2. Association between cognitive scales and
small world index (SWI) by Spearman’s correlations. (A-D) SWI in alpha
and gamma frequency bands (50-70Hz) showed positive correlation with
intelligence quotient and memory quotient after FDR correction.
Figure 3. Frequency spectral analysis in drug-resistant temporal
lobe epilepsy (TLE) patients. (A) & (B) Across-channel grand average
of Power spectral density (PSD) showed increased delta power and
decreased alpha power in drug-resistant TLE groups, compared to
controls. (C) & (D) Increased delta power in TLE groups are
mainly over the anterior regions. For gamma frequencies, the relative
PSD over the central, frontal, and temporal areas was lower in the TLE
groups than in the controls.
Figure
4. Amyloid-β (Aβ) and phosphorated-Tau (p-Tau)
immunofluorescence in hippocampus of drug-resistant TLE. (A)Different Aβ expression between NC and AC groups is observed, with
similar Neun expression. (B) The p-Tau deposition is more
severe in AC group, compared with NC group, while the expression of MAP2
is similar in two groups. (C) Quantitative analysis showed
substantial differences between NC and AC groups in Aβ and p-Tau
expression. NC: normal cognition; AC: abnormal cognition.