Graph theory analysis
In the current study, TLE patients with WIS scores in the NC (n =
31), AC (n = 30), and HC (n = 18) groups were included for
further analyses. The results of the graph theory are presented in Table
1 and Figure 1. SWI in the AC group tended to be increased in delta and
theta frequency but decreased in alpha frequency compared to that in the
NC group and controls. Group differences were significant for alpha
(p NC-AC=0.006). Increased SWI in the fast rhythm
was observed in both TLE groups compared with controls. However, in the
gamma frequency, SWI in the AC group declined to the level of SWI in
controls. SWI in the AC group was significantly lower than that in the
NC group at 50–70 Hz (p NC-HC=0.031,p NC-AC=0.031) after applying the FDR correction.
Spearman’s correlations between the WIS and SWI were tested in each
frequency band (Supplemental Table 1). After applying a multiple test
correction, the results showed that SWI in alpha and 50–70 Hz was
positively correlated with IQ (alpha: r = 0.434, P =
0.003; 50–70 Hz: r = 0.352, p = 0.021) and MQ (alpha:r = 0.373, P = 0.010; 50–70 Hz: r = 0.412,p = 0.007) (Figure 2). The results of Spearman’s correlation
analysis of the SWI and cognition scores are summarized in Supplemental
Table 1.
Group comparisons of functional connectivity between all ROIs were
performed using EEG data from 40-channel EEG recordings. After applying
NBS, no significant differences were observed.