Conclusion:
Maintaining a high level of vigilance is essential when it comes to
detecting CNS involvement in CML patients who have received imatinib
treatment, especially those in a blast crisis. Aggressive treatment
strategies, including intrathecal chemotherapy, adjusting TKI for better
CNS penetration, and even considering allogeneic stem cell
transplantation, are crucial in such cases. Additional research is
warranted to improve the concept of CNS prophylaxis for high-risk
patients.
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