Screening Criteria
All pregnant individuals at increased risk for preterm delivery, including: Individuals with a history of prior pre-term delivery or PPROM Individuals with a history of two or more unexplained first-trimester SABs Individuals with multiple gestations Individuals who are receiving a cerclage
Antibiotics Regimen 1st Line Regimen Alternative Regimen
Ureaplasma Azithromycin 500mg PO x 1 then 250mg PO daily for a total of 7 days Clindamycin 300mg PO BID x 7 days
Mycoplasma Clindamycin 300mg PO BID x 7 days
Ureaplasma + Mycoplasma
Azithromycin 500mg PO x 1 then 250mg PO daily for a total of 7 days And Clindamycin 300mg PO BID x 7 days
Partner Treatment Doxycycline
Rescreening Test-of-cure can be offered 3-4 weeks following completion of antibiotic therapy with re-treatment x 1 if still positive Treatment with more than two courses of antibiotics is not recommended