CONCLUSIONS
The present meta-analysis suggests using NIV-NAVA as a weaning mode may reduce extubation failure within the first 72 hours for extremely premature infants. With respect to the rates of BPD, NEC, and ROP, there was not sufficient evidence that NIV-NAVA was superior to conventional NIV. Preliminary research indicates that NIV-NAVA has a promising future, but large randomized crossover studies and long-term studies are yet to be conducted. Consequently, to assess whether extubated to NIV-NAVA improve weaning success and clinical outcomes after long-term intubation, further original RCTs and data are needed.