References
  1. Massive bleeding in cardiac surgery. Definitions, predictors and challenges A Petrou1, P Tzimas1, S Siminelakis2. HIPPOKRATIA 2016, 20, 3: 179-186.
  2. Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting Kamrouz Ghadimi, MD, Jerrold H. Levy, MD, FAHA, FCCM, and Ian J. Welsby, BSc, MBBS, FRCA
  3. Transfusion and Pulmonary Morbidity After Cardiac Surgery. Colleen Koch, MD, MS, Liang Li, PhD, Priscilla Figueroa, MD, Tomislav Mihaljevic, MD, Lars Svensson, MD, PhD, and Eugene H. Blackstone, MD. Departments of Cardiothoracic Anesthesia, Quantitative Health Sciences, Laboratory Medicine and Clinical Pathology, and Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio. Ann Thorac Surg 2009;88:1410 – 8.
  4. The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. Vlaar, et al. BLOOD, 21 APRIL 2011 VOLUME 117, NUMBER 16. Prepublished online as Blood First Edition paper, February 16, 2011; DOI 10.1182/blood-2010-10- 313973.
  5. Comparison of 4-Factor Prothrombin Complex Concentrate With Frozen Plasma for Management of Hemorrhage During and After Cardiac Surgery A Randomized Pilot Trial.Keyvan Karkouti, MD1,2;Justyna Bartoszko, MD1,2;Deep Grewal, MD1; et al Cielo Bingley, RN1 ;Chantal Armali, BSc3;Jo Carroll, BHA1;Hans-Peter Hucke, PhD4;Amie Kron, MSc3;Stuart A. McCluskey, MD1,2;Vivek Rao, MD2,5;Jeannie Callum, MD3,6, JAMA Network Open.2021;4(4):e213936. doi:10.1001/jamanetworkopen.2021.3936
  6. Prothrombin Complex Concentrate in Cardiac Surgery: A Systematic Review and Meta-Analysis
Marius Roman 1, Fausto Biancari 2, Aamer B Ahmed 3, Seema Agarwal 4, Leon Hadjinikolaou 5, Ali Al-Sarraf 5, Geoff Tsang 6, Aung Y Oo 7, Mark Field 8, Francesco Santini 9, Giovanni Mariscalco 10jathoracsur.2018.10.01
Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery.
Giangiuseppe Cappabianca1† , Giovanni Mariscalco2*† , Fausto Biancari3 , Daniele Maselli4 , Francesca Papesso1 , Marzia Cottini1 Sandro Crosta5 , Simona Banescu5 , Aamer B. Ahmed6 and Cesare Beghi. Cappabianca et al. Critical Care (2016) 20:5. DOI 10.1186/s13054-015-1172-6
Comparison of 4-Factor Prothrombin Complex Concentrate With Frozen Plasma for Management of Hemorrhage During and After Cardiac Surgery A Randomized Pilot Trial. Keyvan Karkouti, MD; Justyna Bartoszko, MD; Deep Grewal, MD; Cielo Bingley, RN; Chantal Armali, BSc; Jo Carroll, BHA; Hans-Peter Hucke, PhD; Amie Kron, MSc; Stuart A. McCluskey, MD; Vivek Rao, MD; Jeannie Callum, MD. JAMA Network Open. 2021;4(4):e213936. doi:10.1001/jamanetworkopen.2021.3936.
An Exploratory Cohort Study Comparing Prothrombin Complex Concentrate and Fresh Frozen Plasma for the Treatment of Coagulopathy After Complex Cardiac Surgery. Ortmann, Erik MD, DESA*; Besser, Martin W. MRCP, FRCPath; Sharples, Linda D. PhD; Gerrard, Caroline*; Berman, Marius MD, FRCS (CTh)§; Jenkins, David P. BSc, MBBS, FRCS(Eng), MS(Lond), FRCS(CTh)§; Klein, Andrew A. MBBS, FRCA* . Anesthesia & Analgesia: July 2015 - Volume 121 - Issue 1 - p 26-33
doi: 10.1213/ANE.0000000000000689