What this study adds
Adding a carboxylic acid group to the prototypical phosphodiesterase inhibitor sildenafil produces an analog that is gut-retained and does not enter the circulation in mice.
Malonyl-sildenafil is a carboxylic acid containing analog of sildenafil with low systemic delivery but is equally potent as sildenafil at suppressing proliferation in the colon epithelium of mice.