Conclusion
In conclusion, twin pregnancy was found to be a significant risk factor for maternal renal dysfunction (serum creatinine > 0.8 mg/dL). The rate of maternal renal dysfunction was not significantly different between dichorionic and monochorionic twins. In 13 twin pregnancies with renal dysfunction, the renal function of all women normalized after delivery, without medical intervention. This suggests that pregnancy induces maternal renal dysfunction, which is more pronounced in twins. Careful attention should be paid to maternal renal dysfunction in the management of twin pregnancies.
Acknowledgements: We thank Editage (https://www.editage.com/) for the English language editing. We would like to thank Yoshiro Fujita, a nephrologist, for his valuable comments and advice regarding renal function. We would like to thank Atsushi Kubo for supporting the data collection from medical records.
Disclosure of Interests: The authors declare no conflicts of interest in association with the present study.
Contribution to Authorship: AM was the principal author who participated in the conceptualization, design, data collection and management, and data analysis. HT was the corresponding author, contributed to the design, data collection and management, and data analysis, and drafted the manuscript. YM, TN, MS, NF, YI, AT, TA, and KM contributed to the data collection and management. All authors have read and approved the final manuscript.
Details of Ethics Approval: This study was approved by the Ethics Committee of the Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan (approval date: November 9, 2021; approval number: 2021-422). Informed consent was not required for this study since we used anonymous clinical data.
Data Availability Statement: The data (de-identified participant data) that support the findings of this study are available from the corresponding author (HT) upon reasonable request.