Statistical Analysis
The Wilcoxon rank-sum test was used to analyze clinical characteristics
between the groups.
Alpha
diversity was indicated by the Shannon index, Chao1 index and Simpson
index, through the Wilcoxon rank-sum test. The β-diversity index
compared between groups were directly presented using the Adonis
nonparametric test. The Spearman correlation test was used to assess the
relevance between
clinical
indicators and ASVs.
RESULTS
1. Clinical
parameters of polycystic ovary syndrome and control participants
We
summarized the baseline characteristics of each group of participants
(Table 1). Compared with the control group, the PCOS group had higher
levels of BMI, LH, E2, AMH and T (P<0.05),
while the highest levels of AMH, LH, and total testosterone was found in
the PA group (P<0.05).
As
for the lipid metabolism profile, the levels of low-density lipoprotein
(LDL), triglycerides (TG) and total cholesterol (TC) were significantly
higher in the PCOS group than in the control group (P<0.05)
(Supplementary Table 1).