4. Conclusions
In this review, we reviewed that epigenetic regulation, such as histone
modifications,
DNA
methylation, ncRNAs and REST/NRSF in epilepsy. Increasing evidence
suggests that epigenetic mechanisms play a functional role in
epileptogenesis and therapeutic reconstruction of the epigenome is an
effective antiepileptogenic therapy. In addition, some drugs may also
play an antiepileptic role through epigenetic mechanisms. Studying the
role of various epigenetic mechanisms in epilepsy may be beneficial to
understand the epileptogenesis and therapy of epilepsy. At present,
there are many ways of epigenetic regulation, but the mechanisms of
epigenetic regulation in epileptogenesis and therapy of epilepsy is not
fully understood. Therefore, targeting epigenetic regulation may be a
new approach to suppress seizures and the progression of epilepsy, which
is yet to be discovered and explored.