2.2 Histone modifications
Currently, histone tails and globular domains contain multiple targets
of several posttranslational modifications, such as ubiquitination,
phosphorylation, acetylation, methylation and ADP-ribosylation. Previous
studies have supported that epilepsy and seizures can induce histone
modifications and histone modifications also influence epileptogenesis.
Therefore, we will focus on the roles of histone acetylation and histone
methylation in epilepsy.