BDNF-AS |
Concerning epilepsy, a study found that the expression of BDNF
is upregulated in human neocortex removed as a treatment of intractable
seizures, whereas the levels of BDNF-AS are significantly decreased.
BDNF-AS can negatively regulate BDNF expression. |
(Lipovich et al.,
2012; Modarresi et al., 2012) |
LncRNA H19 |
LncRNA H19 suppresses microRMA-let-7b to regulate
hippocampal neuron apoptosis and lncRNA H19 also regulates JAK/STAT
signaling to promote activation of hippocampal glial cell in TLE rat
model. |
(Han et al., 2018a; Han et al., 2018b) |
LncRNA FTX |
LncRNA FTX regulates microRNA-21-5p/SOX7 axis to suppress
apoptosis of hippocampal neurons in a rat model of TLE. |
(Li et al.,
2019b) |
LncRNA UCA1 |
LncRNA UCA1 regulates microRNA-495/Nrf2-ARE signal pathway
to suppress seizure-induced brain injury and seizure, and lncRNA-UCA1
has dynamic regulation effect on NF-κB in hippocampus of epilepsy rats.
LncRNA UCA1 regulates microRNA-375/SFRP1-mediated WNT/β-Catenin pathway
to alleviate aberrant hippocampal neurogenesis in KA-induced epilepsy
model. LncRNA UCA1 regulates microRNA-203-mediated MEF2C/NF-κB signaling
pathway to inhibit inflammation in epilepsy. |
(Wang et al., 2017; Geng
et al., 2018; Yu et al., 2020; Diao et al., 2021) |
LncRNA MALAT1 |
Down-regulation of LncRNA MALAT1 protects hippocampal
neurons against excessive autophagy and apoptosis via the PI3K/Akt
signaling pathway in rats with epilepsy. |
(Wu and Yi,
2018) |
LncRNA PVT1 |
Silencing lncRNA PVT1 can downregulate WNT signaling
pathway to promote the expression of BDNF and suppress the activation of
hippocampal astrocytes in epileptic rats. |
(Zhao et al.,
2019b) |
LncRNA ILF3-AS1 |
LncRNA ILF3-AS1 suppresses microRNA-212 to mediate
epileptogenesis in the hippocampus and targets microRNA-212 to promote
the expression of inflammatory cytokines and MMPs in TLE. |
(Cai et al.,
2020) |
LncRNA ZFAS1 |
LncRNA ZFAS1 upregulates microRNA-421 to activate the
PI3K/AKT pathway, thereby inhibiting apoptosis and autophagy of
hippocampal neurons in epilepsy. LncRNA ZFAS1 can also promote neuronal
apoptosis and inflammation response, thereby aggravating the development
of epilepsy. |
(Hu et al., 2020a; He et al., 2021a) |
LncRNA MALAT1 |
LncRNA MALAT1 regulates dendritic spine density.
Downregulated lncRNA MALAT1 regulates the PI3K/Akt signaling pathway to
protect hippocampal neurons against excessive autophagy and apoptosis in
rats with epilepsy. |
(Wu and Yi, 2018; Murugan and Boison,
2020) |
LncRNA BC1 |
Loss the lncRNA BC1 reduced convulsive thresholds. |
(Murugan and Boison, 2020) |
LncRNA KCNH5-1 |
LncRNA KCNH5-1
plays a key vital role in developing TLE with Hippocampal Sclerosis
(HS). |
(Wang et al., 2022) |
LncRNA NEAT1 |
LncRNA NEAT1 is responsive to neuronal activity and is
associated with hyperexcitability states. LncRNA NEAT1 also targets
microRNA-129-5p and regulates Notch signaling to regulate inflammatory
responses in epilepsy. |
(Barry et al., 2017; Wan and Yang,
2020) |
LncRNA GAS5 |
LncRNA GAS5 inhibits microRNA-219 to affect CaMKIIγ/NMDAR
pathway and promote the progression of epilepsy. LncRNA GAS5 silencing
regulates microRNA-135a-5p to suppress the expression of KCNQ3, thereby
preventing the progression of epilepsy. |
(Li et al., 2019a; Zhao et
al., 2022) |
LncRNA TUG1 |
LncRNA TUG1 may be a biomarker of TLE diagnosis in
children, and regulates miR-199a-3p to affect cell activity and
apoptosis of hippocampal neuron. |
(Li et al., 2021) |
LncRNA XIST |
LncRNA XIST sponges miR-29c-3p and regulates NFAT5
expression to promote the secretion of inflammatory cytokines in
LPS-treated CTX-TNA2. |
(Zhang et al., 2021) |
LncRNA Nespas |
LncRNA Nespas, as a regulator of microRNA-615-3p,
inhibits the PI3K/Akt/mTOR pathway to suppress apoptosis of epileptiform
hippocampal neurons by upregulating Psmd11. |
(Feng et al.,
2021) |
LncRNA SNHG1 |
SP1 activated-lncRNA SNHG1 regulates microRNA-154-5p/TLR5
axis to mediate the development of epilepsy. |
(Zhao et al.,
2020) |
Circ-EFCAB2 |
Circ-EFCAB2 may be potential therapeutic targets and
biomarkers for TLE patients. |
(Li et al., 2018b) |
Circ-UBQLN1 |
Circ-UBQLN1 upregulates microRNA-155-mediated SOX7,
thereby inhibiting apoptosis and oxidative stress and promoting
proliferation of hippocampal neurons in epilepsy. |
(Zhu et al.,
2021) |
Circ-DROSHA |
Circ-DROSHA may be potential therapeutic targets and
biomarkers for TLE patients. Circ-DROSHA can regulate
microRNA-106b-5p/MEF2C axis to reduce the neural damage in TLE cell
model. |
(Li et al., 2018b; Zheng et al., 2021) |
Circ-ANKMY2 |
Circ-ANKMY2 regulates the microRNA-106b-5p/FOXP1 axis to
affect TLE progression. |
(Lin et al., 2020) |
Circ-Hivep2 |
Circ-Hivep2 regulates microRNA-181a-5p/SOCS2 signaling to
promote microglia activation and inflammation in KA-induced epileptic
mice model. |
(Xiaoying et al., 2020) |