Highlights
1. In epilepsy, the epigenetic regulation is involved in epileptogenesis. We summarize the roles of histone modifications, DNA methylation, ncRNAs and REST/NRSF in epilepsy.
2. MicroRNAs may be the biomarkers for the diagnosis of epilepsy and is involved in treatment of epilepsy. LncRNAs may regulate epilepsy by targeting microRNA. As one of the regulatory mechanisms of microRNAs, m6A modification may be involved in the pathogenesis of epilepsy.
3. The mechanisms of epigenetic regulation in epilepsy may provide new strategies for the treatment of epilepsy.