4. Conclusions
In this review, we reviewed that epigenetic regulation, such as histone modifications, DNA methylation, ncRNAs and REST/NRSF in epilepsy. Increasing evidence suggests that epigenetic mechanisms play a functional role in epileptogenesis and therapeutic reconstruction of the epigenome is an effective antiepileptogenic therapy. In addition, some drugs may also play an antiepileptic role through epigenetic mechanisms. Studying the role of various epigenetic mechanisms in epilepsy may be beneficial to understand the epileptogenesis and therapy of epilepsy. At present, there are many ways of epigenetic regulation, but the mechanisms of epigenetic regulation in epileptogenesis and therapy of epilepsy is not fully understood. Therefore, targeting epigenetic regulation may be a new approach to suppress seizures and the progression of epilepsy, which is yet to be discovered and explored.