LncRNAs Mechanisms References
BDNF-AS Concerning epilepsy, a study found that the expression of BDNF is upregulated in human neocortex removed as a treatment of intractable seizures, whereas the levels of BDNF-AS are significantly decreased. BDNF-AS can negatively regulate BDNF expression. (Lipovich et al., 2012; Modarresi et al., 2012)
LncRNA H19 LncRNA H19 suppresses microRMA-let-7b to regulate hippocampal neuron apoptosis and lncRNA H19 also regulates JAK/STAT signaling to promote activation of hippocampal glial cell in TLE rat model. (Han et al., 2018a; Han et al., 2018b)
LncRNA FTX LncRNA FTX regulates microRNA-21-5p/SOX7 axis to suppress apoptosis of hippocampal neurons in a rat model of TLE. (Li et al., 2019b)
LncRNA UCA1 LncRNA UCA1 regulates microRNA-495/Nrf2-ARE signal pathway to suppress seizure-induced brain injury and seizure, and lncRNA-UCA1 has dynamic regulation effect on NF-κB in hippocampus of epilepsy rats. LncRNA UCA1 regulates microRNA-375/SFRP1-mediated WNT/β-Catenin pathway to alleviate aberrant hippocampal neurogenesis in KA-induced epilepsy model. LncRNA UCA1 regulates microRNA-203-mediated MEF2C/NF-κB signaling pathway to inhibit inflammation in epilepsy. (Wang et al., 2017; Geng et al., 2018; Yu et al., 2020; Diao et al., 2021)
LncRNA MALAT1 Down-regulation of LncRNA MALAT1 protects hippocampal neurons against excessive autophagy and apoptosis via the PI3K/Akt signaling pathway in rats with epilepsy. (Wu and Yi, 2018)
LncRNA PVT1 Silencing lncRNA PVT1 can downregulate WNT signaling pathway to promote the expression of BDNF and suppress the activation of hippocampal astrocytes in epileptic rats. (Zhao et al., 2019b)
LncRNA ILF3-AS1 LncRNA ILF3-AS1 suppresses microRNA-212 to mediate epileptogenesis in the hippocampus and targets microRNA-212 to promote the expression of inflammatory cytokines and MMPs in TLE. (Cai et al., 2020)
LncRNA ZFAS1 LncRNA ZFAS1 upregulates microRNA-421 to activate the PI3K/AKT pathway, thereby inhibiting apoptosis and autophagy of hippocampal neurons in epilepsy. LncRNA ZFAS1 can also promote neuronal apoptosis and inflammation response, thereby aggravating the development of epilepsy. (Hu et al., 2020a; He et al., 2021a)
LncRNA MALAT1 LncRNA MALAT1 regulates dendritic spine density. Downregulated lncRNA MALAT1 regulates the PI3K/Akt signaling pathway to protect hippocampal neurons against excessive autophagy and apoptosis in rats with epilepsy. (Wu and Yi, 2018; Murugan and Boison, 2020)
LncRNA BC1 Loss the lncRNA BC1 reduced convulsive thresholds. (Murugan and Boison, 2020)
LncRNA KCNH5-1 LncRNA KCNH5-1 plays a key vital role in developing TLE with Hippocampal Sclerosis (HS). (Wang et al., 2022)
LncRNA NEAT1 LncRNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. LncRNA NEAT1 also targets microRNA-129-5p and regulates Notch signaling to regulate inflammatory responses in epilepsy. (Barry et al., 2017; Wan and Yang, 2020)
LncRNA GAS5 LncRNA GAS5 inhibits microRNA-219 to affect CaMKIIγ/NMDAR pathway and promote the progression of epilepsy. LncRNA GAS5 silencing regulates microRNA-135a-5p to suppress the expression of KCNQ3, thereby preventing the progression of epilepsy. (Li et al., 2019a; Zhao et al., 2022)
LncRNA TUG1 LncRNA TUG1 may be a biomarker of TLE diagnosis in children, and regulates miR-199a-3p to affect cell activity and apoptosis of hippocampal neuron. (Li et al., 2021)
LncRNA XIST LncRNA XIST sponges miR-29c-3p and regulates NFAT5 expression to promote the secretion of inflammatory cytokines in LPS-treated CTX-TNA2. (Zhang et al., 2021)
LncRNA Nespas LncRNA Nespas, as a regulator of microRNA-615-3p, inhibits the PI3K/Akt/mTOR pathway to suppress apoptosis of epileptiform hippocampal neurons by upregulating Psmd11. (Feng et al., 2021)
LncRNA SNHG1 SP1 activated-lncRNA SNHG1 regulates microRNA-154-5p/TLR5 axis to mediate the development of epilepsy. (Zhao et al., 2020)
Circ-EFCAB2 Circ-EFCAB2 may be potential therapeutic targets and biomarkers for TLE patients. (Li et al., 2018b)
Circ-UBQLN1 Circ-UBQLN1 upregulates microRNA-155-mediated SOX7, thereby inhibiting apoptosis and oxidative stress and promoting proliferation of hippocampal neurons in epilepsy. (Zhu et al., 2021)
Circ-DROSHA Circ-DROSHA may be potential therapeutic targets and biomarkers for TLE patients. Circ-DROSHA can regulate microRNA-106b-5p/MEF2C axis to reduce the neural damage in TLE cell model. (Li et al., 2018b; Zheng et al., 2021)
Circ-ANKMY2 Circ-ANKMY2 regulates the microRNA-106b-5p/FOXP1 axis to affect TLE progression. (Lin et al., 2020)
Circ-Hivep2 Circ-Hivep2 regulates microRNA-181a-5p/SOCS2 signaling to promote microglia activation and inflammation in KA-induced epileptic mice model. (Xiaoying et al., 2020)