2.2 Histone modifications
Currently, histone tails and globular domains contain multiple targets of several posttranslational modifications, such as ubiquitination, phosphorylation, acetylation, methylation and ADP-ribosylation. Previous studies have supported that epilepsy and seizures can induce histone modifications and histone modifications also influence epileptogenesis. Therefore, we will focus on the roles of histone acetylation and histone methylation in epilepsy.