Abstract
Epilepsy
is a common neurological disorder in which excessive and abnormal
neuronal discharges can be observed and is characterized by recurrent
seizures. The epileptogenesis is usually involved in neuropathological
processes such as ion channel dysfunction, neuronal injury, inflammatory
response, synaptic plasticity, glial cell proliferation and mossin
fibrosis, currently the pathogenesis of epilepsy is not yet completely
understood.
A
growing body of studies have shown that epigenetic regulation, such as
histone modifications, DNA methylation, noncoding RNAs (ncRNAs), and
restrictive element-1 silencing transcription factor/neuron-restrictive
silencing factor (REST/NRSF) are also involved in epilepsy. However, the
functional roles of epigenetics in pathogenesis and treatment of
epilepsy are still to be explored. Therefore, in this review, we will
summarize latest advances concerning the mechanisms of epigenetic
regulation in
epilepsy,
which provide novel insight into therapy and biomarkers for epilepsy.
Key words: epilepsy; DNA methylation; histone modification;
noncoding RNA; N6-methyladenosine; restrictive element-1 silencing
transcription factor/neuron-restrictive silencing factor;