5.Conclusion
Our explorative study showed a possible association between plasma concentrations and fall risk in older TCA users, but not in SSRI users. However, this needs to be interpreted with caution due to the small sample size and accompanying impossibility to perform multivariate analyses in this group. The current study has no direct clinical implications as our findings should be further re-evaluated in a larger cohort. Ideally replication would not only include multivariate assessment, but also include information about medication adherence and concentration measurements around the fall incident. However, this topic is important since it would give us more detailed insight in risk factors determining medication related fall risk and has the potential to personalize clinical decision making, maximizing benefit and minimizing harm in antidepressant use for older persons at risk of falling.