5.Conclusion
Our explorative study showed a possible association between plasma
concentrations and fall risk in older TCA users, but not in SSRI users.
However, this needs to be interpreted with caution due to the small
sample size and accompanying impossibility to perform multivariate
analyses in this group. The current study has no direct clinical
implications as our findings should be further re-evaluated in a larger
cohort. Ideally replication would not only include multivariate
assessment, but also include information about medication adherence and
concentration measurements around the fall incident. However, this topic
is important since it would give us more detailed insight in risk
factors determining medication related fall risk and has the potential
to personalize clinical decision making, maximizing benefit and
minimizing harm in antidepressant use for older persons at risk of
falling.