The discovery of natural product with therapeutics effect is widely growing interest, especially for the treatment of neurodegenerative diseases such as dementia or alzheimer's disease (AD). As there are no effective treatment is available to prevent the development of these disease, dietary intake of foods or plant-based extracts with antioxidant properties might have beneficial effects on human health and improve brain functions. AD or dementia is a neurodegenerative disease thatcauses neuron cell death, brain to shrink impaired cognitive function and leads to memory loss. It induces alterations in the central nervous system with psychological and physiological negative effects.In the present commentary we discuss whether natural productcould be a novel treatment for AD on the basis current clinical trials conducted, there is evidence to suggest that single herbal drugs formulations may offer certain benefits to the approved drugs. In the last decades, attention to herbal or natural drugs increased, they have become a major focus in the quest for AD remedies and may represent a real promise for curing the disease.