AUTHOR CONTRIBUTIONS
The main structure of the article was developed after several
discussions between the co-authors. Yun Wang and Peng Xie contributed
equally to this work. Yun Wang and Peng Xie collected samples, conducted
the laboratory assays, processed sequencing data, conducted statistical
analysis, and wrote the manuscript. Jiyun She contributed to
experimental concepts and design and trained and supervised Yun Wang and
Peng Xie in designing experiments, analyzing data, and writing the
manuscript. Yun Wang, Peng Xie, Aihua Deng, and Kerui Huang performed
the experiments, and Shaogang Fan provided informative suggestions
during the experimental design and revision of the article. All authors
have read and approved the final manuscript.