Conclusions
In conclusion, our results suggest causal associations of lower educational attainment and increased coffee or tea consumption, fat intake, BMI, and smoking with increased risk of OC histological subtypes. Specifically, our study demonstrated that genetically determined years of education was inversely associated with overall OC, and subtypes of LMSOC, HGSOC, IMOC, LGSOC, and EOC. Higher coffee or tea consumption was causally associated with EOC risk. In addition, we found increased dietary fat intake was detrimental for HGSOC, but protective for EOC subtype. Genetic predisposition to a higher BMI was positively associated with the risk of LMSOC, LMMOC, and EOC. Elevated lifetime smoking index was suggestively associated with increased risk overall OC, HGSOC and EOC. Whereas physical activity, sleep duration, insomnia, and alcohol consumption are not associated with any type of OC. These findings have major clinical and public health implications as lifestyle factors can easily be modified. However, the results should be interpreted with caution considering the difficulty in completely ruling out pleiotropy.