Baseline Baseline Baseline Baseline Weighted characteristics after IPW Weighted characteristics after IPW Weighted characteristics after IPW Weighted characteristics after IPW
Perceval SAVR p-value* SMD Perceval SAVR p-value** SMD
N = 265 N = 394 N = 258 N = 394
N (%) or Mean (SD) N (%) or Mean (SD) Weighted % or mean (SE) Weighted % or mean (SE)
Operative charactertistics
Aortic Valve Size
Mean (SD) 25.0 (1.9) 24.0 (2.6) <0.001* 0.455 25.07 (0.12) 23.77 (0.14) <0.001* 0.576
19 - 21mm, small 16 (6.0) 92 (23.4) <0.001* 0.425 6.11 26.37 <0.001* 0.536
22-23mm, medium 65 (24.5) 113 (28.7) 23.2 28.92
24-25mm, large 85 (32.1) 93 (23.6) 31.73 22.4
26-27mm, extra-large 99 (37.4) 72 (18.3) 38.95 17.05
> 27mm 0 (0.0) 24 (6.1) 0 5.26
Operative approach <0.001* 0.282 <0.001* 0.391
Full sternotomy 216 (81.5) 359 (91.1) 78.68 92.01
Minimally invasive approachesa 49 (18.5) 35 (8.9) 21.32 7.99
Cardioplegia used 0.53 0.069 0.37 0.091
None 0 (0.0) 1 (0.3) 0 0.18
Blood 54 (20.4) 91 (23.1) 20.22 24.04
Crystalloid 2 (0.8) 1 (0.3) 0.85 0.27
Both 209 (78.9) 301 (76.4) 78.93 75.52
Cardioplegia delivery method 0.18 -0.062 0.03 -0.185
None 0 (0.0) 1 (0.3) 0 0.18
Antegrade 60 (22.6) 73 (18.5) 26.37 17.58
Retrograde 5 (1.9) 17 (4.3) 1.98 3.85
Both 200 (75.5) 303 (76.9) 71.65 78.38
Median cross-clamp time (minutes) 74.0 (48.0-105.0) 83.0 (64.0-110.0) <0.001* -0.302 77.23 (2.63) 93.87 (2.18) <0.001* -0.407
Median pump time (minutes) 100.0 (69.0-144.0) 110.0 (90.0-156.0) <0.001* -0.315 106.38 (3.32) 129.13 (2.96) <0.001* -0.422
Median OR Time (hours) 4.6 (3.6-5.7) 4.7 (4.0-5.7) 0.025* -0.159 4.71 (0.1) 5.15 (0.08) <0.001* -0.287
Intraoperative blood transfusion 51 (19.2) 61 (15.5) 0.21 0.099 16.82 17.4 0.85 -0.015
Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit Abbreviation: savr - surgical aortic valve replacement; sd - standard deviation; smd - standardized mean difference; cabg: coronary artery bypass graft surgery; cticu – cardiothoracic intensive care unit
aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures aminimally invasive approaches include partial sternotomy, right or left parasternal incision, right thoracotomy, limited (mini) thoracotomy, and other thoracotomy procedures
*p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate *p-values obtained from chi-squared tests, wilcoxon rank-sum tests, or two sample t-tests as appropriate
**p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic) **p-values for dichotomous and categorical variables are corrected, weighted, pearson chi-squared statistics that account for weighted data (design-based f statistic)
*p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests *p-values for continuous variables obtained from adjusted wald tests