3.6 Frequency of confirmed evidence for herb-drug
interactions
In this study, the considerable number of herb-drug interactions was
determined or confirmed with vitro (66 studies) and clinical studies (46
studies, randomized and non-randomized clinical trials) and only 4
herb-drug interactions were based on anecdotal evidence (Fig 2). All
herb-drug interactions were confirmed by one evidence except nine
herb-drug interactions which were confirmed by two evidences. These
pairs were “Cyclophosphamide and Mentha piperita L .” (Vitro and
randomized clinical trial), “Cyclophosphamide and Glycyrrhiza
glabra L.” (Vitro and randomized clinical trial), “Docetaxel andGlycyrrhiza glabra L.” (Vitro and randomized clinical trial),
“Doxorubicin and Valeriana officinalis L.” (Vitro and
non-randomized clinical trial), “Paclitaxel and Glycyrrhiza
glabra L.” (Vitro and randomized clinical trial), “Tamoxifen andMentha piperita L .” (Vitro and randomized clinical trial),
“Tamoxifen and Foeniculum vulgare Mill” (Vitro and
theoretically based on pharmacology), “Tamoxifen and Valeriana
officinalis L.” (Vitro and non-randomized clinical trial) and
“Tamoxifen and Glycyrrhiza glabra L.” (Vitro and randomized
clinical trial). The type of evidence for other herb-drug interactions
is presented in Appendix A.