3.6 Frequency of confirmed evidence for herb-drug interactions
In this study, the considerable number of herb-drug interactions was determined or confirmed with vitro (66 studies) and clinical studies (46 studies, randomized and non-randomized clinical trials) and only 4 herb-drug interactions were based on anecdotal evidence (Fig 2). All herb-drug interactions were confirmed by one evidence except nine herb-drug interactions which were confirmed by two evidences. These pairs were “Cyclophosphamide and Mentha piperita L .” (Vitro and randomized clinical trial), “Cyclophosphamide and Glycyrrhiza glabra L.” (Vitro and randomized clinical trial), “Docetaxel andGlycyrrhiza glabra L.” (Vitro and randomized clinical trial), “Doxorubicin and Valeriana officinalis L.” (Vitro and non-randomized clinical trial), “Paclitaxel and Glycyrrhiza glabra L.” (Vitro and randomized clinical trial), “Tamoxifen andMentha piperita L .” (Vitro and randomized clinical trial), “Tamoxifen and Foeniculum vulgare Mill” (Vitro and theoretically based on pharmacology), “Tamoxifen and Valeriana officinalis L.” (Vitro and non-randomized clinical trial) and “Tamoxifen and Glycyrrhiza glabra L.” (Vitro and randomized clinical trial). The type of evidence for other herb-drug interactions is presented in Appendix A.