Abbreviations: CO2, carbon dioxide; KTP, potassium-titanyl-phosphate; AoRRP, adult-onset recurrent respiratory papillomatosis (RRP);JoRRP, juvenile-onset RRP; NA, not available.
The weighted complication rate for microdebrider treatment of RRP was 0.03 (95% CI 0.00-0.21, n = 6, I2 = 91.08%, P <0.1). The weighted complication rate for CO2 laser treatment was 0.16 (95% CI 0.09-0.25, n =14, I2= 79.19%, p <0.1). The weighted complication rate for KTP laser treatment was 0.04 (95% CI 0.00-0.14, n =4, I2=67.76%, p=0.03). Of the included literature, only three studies reported intraoperative complications, all occurring during surgery using CO2 lasers. Complications in these procedures included vocal cord edema in 3 patients and intratracheal burning in one case. As for postoperative delayed complications, included cases, reported anterior commissure web, vocal scar, glottic stenosis, granulation polyp and atrophy. Among the postoperative complications reported, the largest number of cases was anterior commissure web, regardless of the surgical method used. Specific information on complication types and complication rates is presented in Figure 2.and Table 3.