Introduction
Mucormycosis is an opportunistic infection caused by organisms belonging to the order Mucorales affecting between 0.4 and 1.7 cases per 10,000 of the world’s population as reported in 2012 [1, 2]. Due to COVID-19 mucormycosis has become far more common and is now considered a major health threat [1, 3]. Rhino-orbital-cerebral–mucormycosis (ROCM) is the common type of mucormycosis mostly associated with diabetes mellitus (DM, particularly uncontrolled DM) and less commonly other immunosuppressive conditions such as malignancies, organ transplants, HIV, and long-term broad-spectrum antibiotics or immunosuppressive treatment like steroids which is the conventional treatment for COVID-19 [4].
Despite recent case reports and systematic reviews, we still do not have a strong grasp of mucormycosis, including the possibility of brain invasion, abscess formation, and neurological symptoms. unfortunately, Bhattacharyya et al. reported a high mortality rate of mucormycosis related to COVID-19 (33-80%)[1]. in this article, we will discuss two cases of ROCM with brain abscesses, unusual neurological presentations, and possible effective management.