Introduction
Mucormycosis is an opportunistic infection caused by organisms belonging
to the order Mucorales affecting between 0.4 and 1.7 cases per 10,000 of
the world’s population as reported in 2012 [1, 2]. Due to COVID-19
mucormycosis has become far more common and is now considered a major
health threat [1, 3]. Rhino-orbital-cerebral–mucormycosis (ROCM) is
the common type of mucormycosis mostly associated with diabetes mellitus
(DM, particularly uncontrolled DM) and less commonly other
immunosuppressive conditions such as malignancies, organ transplants,
HIV, and long-term broad-spectrum antibiotics or immunosuppressive
treatment like steroids which is the conventional treatment for COVID-19
[4].
Despite recent case reports and systematic reviews, we still do not have
a strong grasp of mucormycosis, including the possibility of brain
invasion, abscess formation, and neurological symptoms. unfortunately,
Bhattacharyya et al. reported a high mortality rate of mucormycosis
related to COVID-19 (33-80%)[1]. in this article, we will discuss
two cases of ROCM with brain abscesses, unusual neurological
presentations, and possible effective management.