Discussion
A relationship between blood levels of Tacrolimus and an increasing
thickness of left ventricular wall have been described more frequently
with blood levels above 15 ng/mL, however it was also significant with
blood levels between 10 and 15 ng/mL and below 10 ng/mL as in our case5. Also, these patients, usually present nonspecific
symptoms such as asthenia, adynamia and lipothymia. However, a wide
variety of signs and symptoms related with congestive heart failure as
dyspnea, orthopnea, anorexia, fatigue, tachypnea, tachycardia, pulmonary
edema and hepatomegaly have been described 8,12.