Eligible and Exclusion Criteria
Studies that match all the inclusion criteria listed below were
selected:1. Population: cancer patients undergoing ICIs therapy alone or
in combination;2. Interventions: PPIs were prescribed within a treatment
window of 30days before, during or after the first dose of ICIs
therapy;3. Comparison: containing an PPIs-exposed group and a control
group did not;4. Outcome: intact data that have enough information to
calculate HR and their 95% CI for PFS and OS.
Exclusion criteria were as followings:1. Case reports, case series,
comments, reviews, letters, editorials, animal models;2. Inappropriate
or unknown PPIs treatment window;3. Insufficient information to
calculate HRs with 95% CI of PFS or
OS;4. Special populations such as
veterans. Two authors (xing cao and yafei wang) screened the studies
independently and conflicts among them were solved by consensus with a
third author.