Descriptive statistical analysis was applied to the final scores and total comments to calculate mean scores for each stakeholder group. The mean scores (per stakeholder group and per guideline) were then utilised for aggregate analysis in different steps: relative shares of accepted, partially accepted and rejected comments; average scores per guideline category (general/indication-level/molecule-level) in each year (2013-2017); and average scores for guidelines authored by different committees (aggregate result for all years). In the subgroup analysis, the mean scores were calculated for each guideline category and guidelines from a given WP. A separate subgroup analysis was conducted for trade associations and companies.