Concentration-dependent Synergy and Sustainable Farming
In this proof-of-concept study, we harnessed a platform technology that we have previously applied in drug combination optimization towards plant biological yield optimization. Similarly, we also explored approaches used in drug development, such as the Bliss independence model, to assess synergies observed in WisDM Green-pinpointed compound combinations.[21] In the context of sustainability, rationally optimizing yield enhancement may be closely interconnected with concentration-dependent synergy. Appropriately adjusting concentration ratios to achieve optimal outcomes may substantially reduce the use of compounds, and also further reduce the reliance on fertilizer-driven approach to increase yield. For example, the excessive use of fertilizer has affected aquatic life and increased greenhouse gas emissions.[11, 23, 24] Though efforts have been made to protect the environment via approaches, such as controlled-release fertilizer, properly adjusting the concentration ratios of compounds may result in improved outcomes and reduction in fertilizer usage, which may lead to leaching.[13, 24, 25]