Fibrosis is a common process of tissue repair response to multiple
injuries in all chronic progressive diseases, which featured with
excessive deposition of extracellular matrix. Actually fibrosis can
occur in all organs and tends to be nonreversible with the progresses of
the diseases. Different cells types in different organs are involved in
the occurrence and development of fibrosis, i.e. hepatic stellate cell,
pancreatic stellate cell, fibroblasts, myofibroblasts. Present studies
have shown that several programmed cell deaths including apoptosis,
autophagy, ferroptosis, and necroptosis were closely related to organ
fibrosis. Among these programmed cell deathes type, necroptosis, an
emerging regulated cell death type were regard as a huge potential
target to ameliorate organ fibrosis. In this review, we summarized the
role of necroptosis signaling in organ fibrosis, and collected the
present small molecule compounds targeting necroptosis. In addition, we
have discussed the potential challenges, opportunities and open
questions in using necroptosis signaling as a potential target for
antifibrotic therapies.