3. Roles of necroptosis in tissue fibrosis
Fibrosis represents excessive scar formation which occurs when the normal wound healing response exceeds the normal tolerance of the tissue in many organs. Both clinical manifestation and experimental study on animal models indicated that fibrosis is a two-way and reversible process (Weiskirchen et al. 2019). At present, the principles to reverse fibrosis mainly include changeover the chronic tissue damage and phlogosis, the demise of myofibroblasts and fibrolysis of excess matrix scaffold. The in-depth comprehension of the molecular mechanisms of various tissue fibrosis is the prerequisite for finding effective biomarkers or and novel antifibrotic treatment options.