Sensitivity (%) (95%CI)
Specificity (%) (95%CI) PPV (%) (95%CI) NPV (%) (95%CI)
AUC (95%CI)
P-value
≥CIN2 Yes No
ASCUS TS positive 34 83 59.6 (45.8-72.2) 69.6 (63.7-74.9) 29.1 (21.2-38.3) 89.2 (84.1-92.9) 0.646 (0.566-0.727)b <0.001c
TS negative 23 190
hrHPV+ 56 172 98.2 (89.4-99.9) 36.8 (31.1-42.8)) 24.6 (19.2-30.8) 99.9 (93.8-99.9) 0.675 (0.611-0.739)b <0.001d
hrHPV- 1 100
TS+hrHPV positivea 33 68 57.9 (44.1-70.6) 75.0 (69.3-79.9) 32.7 (23.9-42.8) 89.5 (84.6-93.0) 0.665 (0.584-0.756)b 1.000e
TS+hrHPV negativea 24 204
LSIL TS positive 23 34 65.7 (47.7-80.3) 59.0 (47.7-69.5) 40.4 (27.8-54.2) 80.3 (67.8-89.0) 0.624 (0.514-0.734)b 0.004c
TS negative 12 49
hrHPV+ 32 58 91.4 (75.8-97.8) 30.1 (20.8-41.3) 35.6 (25.9-46.4) 89.3 (70.6-97.2) 0.608 (0.502-0.713) 0.004d
hrHPV- 3 25
TS+hrHPV positive 23 25 65.7 (47.7-80.3) 69.9 (58.7-79.2) 47.9 (33.5-62.6) 82.9 (71.6-90.5) 0.678 (0.570-0.786)b 1.000e
TS+hrHPV negative 12 58
ASC-H TS positive 12 3 92.3 (62.1-99.6) 25.0 (1.3-78.1) 80.0 (51.4-94.7) 50.0 (2.7-97.3) 0.587 (0.240-0.934) 1.000c
TS negative 1 1
hrHPV+ 13 3 100.0 (71.7-100.0) 25.0 (1.3-78.1) 81.3 (53.7-95.0) 100.0 (5.5-100.0) 0.625 (0.272-0.978) 1.000d
hrHPV- 0 1
TS+hrHPV positive 12 3 92.3 (62.1-99.6) 25.0 (1.3-78.1) 80.0 (51.4-94.7) 50.0 (2.7-97.3) 0.587 (0.240-0.934) 1.000e
TS+hrHPV negative 1 1
Overall TS positive 69 120 65.7 (55.7-74.5) 66.7 (61.5-71.5) 36.5 (29.7-43.8) 87.0 (82.3-90.6) 0.662 (0.602-0.721)b <0.001c
TS negative 36 240
hrHPV+ 101 233 96.2 (90.0-98.8) 35.1 (30.2-40.3) 30.2 (25.4-35.5) 96.9 (91.8-99.0) 0.656 (0.604-0.709)b <0.001d
hrHPV- 4 126
TS+hrHPV positive 68 96 64.8 (54.8-73.7) 73.3 (68.3-77.7) 41.5 (33.9-49.4) 87.7 (83.3-91.7) 0.690 (0.631-0.750)b 1.000e
TS+hrHPV negative 37 263