|
|
|
|
Sensitivity (%) (95%CI)
|
Specificity (%)
(95%CI)
|
PPV (%)
(95%CI)
|
NPV (%)
(95%CI)
|
AUC (95%CI)
|
P-value
|
≥CIN2 |
|
Yes |
No |
|
|
|
|
|
|
ASCUS |
TS positive |
34 |
83 |
59.6 (45.8-72.2) |
69.6 (63.7-74.9) |
29.1 (21.2-38.3) |
89.2 (84.1-92.9) |
0.646
(0.566-0.727)b
|
<0.001c
|
|
TS negative |
23 |
190 |
|
|
|
|
|
|
|
hrHPV+ |
56 |
172 |
98.2 (89.4-99.9) |
36.8 (31.1-42.8)) |
24.6
(19.2-30.8) |
99.9 (93.8-99.9) |
0.675 (0.611-0.739)b
|
<0.001d
|
|
hrHPV- |
1 |
100 |
|
|
|
|
|
|
|
TS+hrHPV positivea
|
33 |
68 |
57.9 (44.1-70.6) |
75.0 (69.3-79.9) |
32.7 (23.9-42.8) |
89.5 (84.6-93.0) |
0.665
(0.584-0.756)b
|
1.000e
|
|
TS+hrHPV negativea
|
24 |
204 |
|
|
|
|
|
|
LSIL |
TS positive |
23 |
34 |
65.7 (47.7-80.3) |
59.0 (47.7-69.5) |
40.4 (27.8-54.2) |
80.3 (67.8-89.0) |
0.624
(0.514-0.734)b
|
0.004c
|
|
TS negative |
12 |
49 |
|
|
|
|
|
|
|
hrHPV+ |
32 |
58 |
91.4 (75.8-97.8) |
30.1 (20.8-41.3) |
35.6
(25.9-46.4) |
89.3 (70.6-97.2) |
0.608 (0.502-0.713) |
0.004d
|
|
hrHPV- |
3 |
25 |
|
|
|
|
|
|
|
TS+hrHPV positive |
23 |
25 |
65.7 (47.7-80.3) |
69.9 (58.7-79.2) |
47.9 (33.5-62.6) |
82.9 (71.6-90.5) |
0.678
(0.570-0.786)b
|
1.000e
|
|
TS+hrHPV negative |
12 |
58 |
|
|
|
|
|
|
ASC-H |
TS positive |
12 |
3 |
92.3 (62.1-99.6) |
25.0 (1.3-78.1) |
80.0
(51.4-94.7) |
50.0 (2.7-97.3) |
0.587 (0.240-0.934) |
1.000c
|
|
TS negative |
1 |
1 |
|
|
|
|
|
|
|
hrHPV+ |
13 |
3 |
100.0 (71.7-100.0) |
25.0 (1.3-78.1) |
81.3
(53.7-95.0) |
100.0 (5.5-100.0) |
0.625 (0.272-0.978) |
1.000d
|
|
hrHPV- |
0 |
1 |
|
|
|
|
|
|
|
TS+hrHPV positive |
12 |
3 |
92.3 (62.1-99.6) |
25.0 (1.3-78.1) |
80.0
(51.4-94.7) |
50.0 (2.7-97.3) |
0.587 (0.240-0.934) |
1.000e
|
|
TS+hrHPV negative |
1 |
1 |
|
|
|
|
|
|
Overall |
TS positive |
69 |
120 |
65.7 (55.7-74.5) |
66.7 (61.5-71.5) |
36.5 (29.7-43.8) |
87.0 (82.3-90.6) |
0.662
(0.602-0.721)b
|
<0.001c
|
|
TS negative |
36 |
240 |
|
|
|
|
|
|
|
hrHPV+ |
101 |
233 |
96.2 (90.0-98.8) |
35.1 (30.2-40.3) |
30.2
(25.4-35.5) |
96.9 (91.8-99.0) |
0.656 (0.604-0.709)b
|
<0.001d
|
|
hrHPV- |
4 |
126 |
|
|
|
|
|
|
|
TS+hrHPV positive |
68 |
96 |
64.8 (54.8-73.7) |
73.3 (68.3-77.7) |
41.5 (33.9-49.4) |
87.7 (83.3-91.7) |
0.690
(0.631-0.750)b
|
1.000e
|
|
TS+hrHPV negative |
37 |
263 |
|
|
|
|
|
|