|
DMSO |
CBD3063 |
|
Total Ca2+ currents |
Total Ca2+
currents |
Activation |
|
|
V1/2 |
-0.665 ± 1.091 (13) |
0.971 ± 2.338
(16) |
k |
7.429 ± 0.991 (13) |
11.004 ± 2.181 (16) |
Inactivation |
|
|
V1/2 |
-17.081 ± 2.647 (13) |
-20.944 ± 3.182
(16) |
k |
-10.916 ± 2.186 (13) |
-14.132 ± 2.880 (16) |
|
N-type Ca2+ currents |
N-type Ca2+
currents |
Activation |
|
|
V1/2 |
-5.993 ± 0.680 (12) |
-5.275 ± 0.669
(17) |
k |
5.266 ± 0.570 (12) |
5.616 ± 0.566 (17) |
Inactivation |
|
|
V1/2 |
-28.936 ± 2.206 (12) |
-31.129 ± 2.169
(17) |
k |
-15.101 ± 2.011 (12) |
-17.247 ± 2.104 (17) |
|
L-type Ca2+ currents |
L-type Ca2+
currents |
Activation |
|
|
V1/2 |
-3.677 ± 0.791 (8) |
-2.704 ± 0.710
(7) |
k |
5.797 ± 0.678 (8) |
5.528 ± 0.615 (7) |
Inactivation |
|
|
V1/2 |
-10.531 ± 0.875 (8) |
-10.128 ± 2.133
(7) |
k |
-4.512 ± 0.848 (8) |
-4.961 ± 1.976 (7) |
|
P/Q-type Ca2+ currents |
P/Q-type
Ca2+ currents |
Activation |
|
|
V1/2 |
-3.703 ± 0.987 (9) |
-3.265 ± 0.824
(7) |
k |
5.375 ± 0.835 (9) |
4.186 ± 0.663 (7) |
Inactivation |
|
|
V1/2 |
-18.283 ± 1.478 (9) |
-18.667 ± 1.688
(7) |
k |
-7.593 ± 1.287 (9) |
-9.396 ± 1.470 (7) |
|
R-type Ca2+ currents |
R-type Ca2+
currents |
Activation |
|
|
V1/2 |
-8.118 ± 0.842 (7) |
-4.098 ± 0.693
(11) |
k |
6.493 ± 0.736 (7) |
7.244 ± 0.579 (11) |
Inactivation |
|
|
V1/2 |
-23.745 ± 3.57 (7) |
-16.840 ± 2.186
(11) |
k |
-13.155 ± 3.325 (7) |
-11.870 ± 1.850 (11) |
|
T-type Ca2+ currents |
T-type Ca2+
currents |
Activation |
|
|
V1/2 |
-16.859 ± 0.722 (11) |
-10.982 ± 1.992
(10) |
k |
5.736 ± 0.636 (11) |
9.924 ± 1.628 (10) |
Inactivation |
|
|
V1/2 |
-41.506 ± 1.708 (11) |
-35.122 ± 2.752
(10) |
k |
-9.884 ± 1.585 (11) |
-12.929 ± 2.490 (10) |
|
Na+ currents |
Na+
currents |
Activation |
|
|
V1/2 |
-23.336 ± 0.663 (9) |
-21.738 ± 0.852
(12) |
k |
3.514 ± 0.576 (9) |
4.749 ± 0.744 (12) |
Inactivation |
|
|
V1/2 |
-37.602 ± 3.112 (9) |
-32.552 ± 2.084
(12) |
k |
-16.081 ± 3.278 (9) |
-12.003 ± 1.936 (12) |