Compounds identified as active in calcium imaging (Figure 2A ). Mw, molecular weight (Da); BBB score, indicates probability of compound having CNS exposure where scores in the range [4-6] correctly predicted 90.3% of CNS drugs (Gupta, Lee, Barden & Weaver, 2019); LogS(7.4), predicted solubility (M) at pH 7.4; cLogP, predicted lipophilicity coefficient in octanol/water; HBD, number of hydrogen-bond donors; HBA, number of hydrogen bond acceptors; RO5, binary (Y/N) assignment of complying with Lipinski rule-of-5 (Lipinski, 2004); NHOH, number of polar NH and OH hydrogens; RotB, number of rotatable bonds; TPSA, topological polar surface area (Ų); QED, Quantitative Estimate of Druglikeness where a score of 1 indicates all properties are favorable (Bickerton, Paolini, Besnard, Muresan & Hopkins, 2012). Properties calculated with RDKit and ChemAxon modules.