A rationally designed selective peptidomimetic modulator of CaV2.2 (N-type) voltage-gated calcium channels for chronic pain
Kimberly Gomez1,2†, Ulises Santiago3†, Aida Calderon-Rivera1,2, Paz Duran1,2, Santiago Loya-Lopez1,2, Angie Dorame4, Aude Chefdeville4, Aubin Moutal4, Dongzhi Ran5, Samantha Perez-Miller1,2, Yi Lu5, Xia Liu5, Handoko6, Paramjit S. Arora6, Marcel Patek7, Carlos J. Camacho3,*, and Rajesh Khanna1,2,*
1Department of Molecular Pathobiology, College of Dentistry, New York University, 433 First Avenue, 8thfloor, New York, NY, 10010, USA.
2NYU Pain Research Center, 433 First Avenue, New York, NY 10010, USA.
3Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
4Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
5Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China
6Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.
7Bright Rock Path LLC, Tucson, Arizona, USA.
Contributed equally to this work
*Correspondence to:
Dr. Carlos J. Camacho, Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA. Email:ccamacho@pitt.edu or
Dr. Rajesh Khanna, Department of Molecular Pathobiology, College of Dentistry, New York University, 433 First Avenue, 8Thfloor, New York, NY, 10010, USA. Office phone: (520) 271-0433; Email:rk4272@nyu.edu
Data Availability Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions.