3- Innate immune responses to SARS-CoV-2
Based on the accumulated data for previous coronavirus infections, the innate immune response plays a crucial role in the protective or destructive responses and may open a window for immune intervention. Active viral replication leads to hyper-production interferon (IFN) type I and influx of neutrophils and macrophages, which are the major sources of pro-inflammatory cytokines (C. Huang et al., 2020).