Overall biologic non-response
All biologic non-responders, N=27 (OMA [44.4%,12/27], MEPO [55.6%,15/27]), were combined and compared with the SNB group and responder groups. Compared to SNB subjects, at baseline, combined non-responders (CNRs) (Table 3) had significantly more AHE, worse ACQ6 and worse lung function. Furthermore, they were significantly more mOCS dependent, more atopic and had a larger proportion of multiple AHE.
Compared to both biologic responders, CNRs had significantly worse baseline ACQ6 and greater prevalence of anxiety. In comparison with MEPO responders, a significantly larger proportion of CNRs were female, had depression, dysfunctional breathing and multiple AHE. Furthermore, CNRs had significantly more AHE at baseline and had younger asthma onset. Compared to OMA responders, there were no notable differences apart from those conferred by qualifying criteria (more Atopy/ lower Maximum PBE).