Overall biologic non-response
All biologic non-responders, N=27 (OMA [44.4%,12/27], MEPO
[55.6%,15/27]), were combined and compared with the SNB group and
responder groups. Compared to SNB subjects, at baseline, combined
non-responders (CNRs) (Table 3) had significantly more AHE, worse ACQ6
and worse lung function. Furthermore, they were significantly more mOCS
dependent, more atopic and had a larger proportion of multiple AHE.
Compared to both biologic responders, CNRs had significantly worse
baseline ACQ6 and greater prevalence of anxiety. In comparison with MEPO
responders, a significantly larger proportion of CNRs were female, had
depression, dysfunctional breathing and multiple AHE. Furthermore, CNRs
had significantly more AHE at baseline and had younger asthma onset.
Compared to OMA responders, there were no notable differences apart from
those conferred by qualifying criteria (more Atopy/ lower Maximum PBE).