Early-onset is defined as having an age of asthma onset<18 years. Adult-onset is defined as having an age of asthma onset ≥18 years. † of those who completed biologic trials, i.e.: did not withdraw due to any reason. A= Chi-squared tests were performed to assess biologic use across the four age-of-onset/sex clusters. B= Chi-squared tests were performed to assess biologic response to Omalizumab across the four age-of-onset/sex clusters. C= Chi-squared tests were performed to assess biologic response to Mepolizumab across the four age-of-onset/sex clusters.