FEV1: forced expiratory volume in one second. BMI: Body mass index. Exacerbations: incidence of exacerbations requiring OCS / increase in maintenance OCS in the past 12 months before biologic approval. AHE: acute healthcare encounters, which include Emergency department/ hospital admissions. Multiple AHE: >1 AHE in the past 12 months before biologic approval. mOCS: maintenance oral corticosteroids. BMI: Body mass index. Obesity: BMI≥30kgm-2. ICU: Intensive care unit. ACQ6: asthma control questionnaire 6. AQLQ: Asthma Quality of Life Questionnaire. HADS: hospital anxiety and depression scale. Adult onset: asthma age of onset ≥18 years. Multiple logistic regression was performed (backward variable selection) using baseline variables trending towards significance (P<0.2). AUC: Area under the Receiver operating characteristic curve.