Results:
Compared with HCs, there was a differential mRNA expression for 9 aging-related gene in peripheral blood of asthma patients. Besides, the methylation level of the 9 aging-related genes were also altered in asthma patients, and a total of 68 CpG sites were associated with the severity of asthma. Notably, 10 of the 68 CpG sites were significantly associated with pulmonary function parameters. Moreover, ROC curve and PCA analysis showed that the candidate differential methylation sites (DMSs) can be used as potential biomarkers for asthma.