Results:
Compared with HCs, there was a differential mRNA expression for 9
aging-related gene in peripheral blood of asthma patients. Besides, the
methylation level of the 9 aging-related genes were also altered in
asthma patients, and a total of 68 CpG sites were associated with the
severity of asthma. Notably, 10 of the 68 CpG sites were significantly
associated with pulmonary function parameters. Moreover, ROC curve and
PCA analysis showed that the candidate differential methylation sites
(DMSs) can be used as potential biomarkers for asthma.