Authors’ contributions
YY: carried out the experiments, analyzed and interpreted the data and drafted the manuscript. YY, YL and WM, YM: collected clinical samples. WL, DX, QL, ZY and WS: performed the experiments and statistical analysis. XY, QX, LH, QX and LC: analyzed and interpreted the data, provided the project funding and revised the manuscript. LC: analyzed and interpreted the data, revised the manuscript and finally approved the version of the manuscript for publication. All authors provided critical feedback and helped shape the research, analysis and manuscript.