Background:
Asthma is a complex pulmonary inflammatory disease which is common among
older adults. Aging-related alterations have also been found in
structural cells and immune cells of asthma patients. Nonetheless,
the underlying mechanism by which differenced aging-related gene
contributes to asthma pathology remains unclear. Of note, DNA
methylation (DNAm) have been proven to be play a critical mechanism for
age-related gene expression changes However, the
methylation changes of aging-related genes in asthma patients is
still obscure.