Background:
Asthma is a complex pulmonary inflammatory disease which is common among older adults. Aging-related alterations have also been found in structural cells and immune cells of asthma patients. Nonetheless, the underlying mechanism by which differenced aging-related gene contributes to asthma pathology remains unclear. Of note, DNA methylation (DNAm) have been proven to be play a critical mechanism for age-related gene expression changes However, the methylation  changes of aging-related genes in asthma patients is still obscure.