Selexipag dosing
Selexipag was commenced at 200 μg twice daily, following the protocol
used in the GRIPHON study, increasing by 200 μg twice daily every seven
days if side effects were tolerable.6 The mean time to reach
an individual maintenance dose was 67 days (± 26) and the mean total
daily maintenance dose was 1830 μg (± 548) at the end of the titration
period. (Table 2 ). Maintenance doses were stratified as
low-dose in 10% (n=2), medium-dose in 70% (n=14) and high-dose in 20%
(n=4). (Table 3 ) Selexipag doses were reviewed at 6 months post
initiation to ascertain if there were any subsequent dose titrations.
These were not significantly different from individual maintenance doses
established at the end of the titration period (p=0.699). (Table
2 )