Selexipag dosing
Selexipag was commenced at 200 μg twice daily, following the protocol used in the GRIPHON study, increasing by 200 μg twice daily every seven days if side effects were tolerable.6 The mean time to reach an individual maintenance dose was 67 days (± 26) and the mean total daily maintenance dose was 1830 μg (± 548) at the end of the titration period. (Table 2 ). Maintenance doses were stratified as low-dose in 10% (n=2), medium-dose in 70% (n=14) and high-dose in 20% (n=4). (Table 3 ) Selexipag doses were reviewed at 6 months post initiation to ascertain if there were any subsequent dose titrations. These were not significantly different from individual maintenance doses established at the end of the titration period (p=0.699). (Table 2 )