Key points
- Most effective topical therapy gives the CRS patients a lower chance
of invasive intervention in terms of sinus surgery.
- The modification of the delivery system has been developed focusing on
the distribution method of the drug into the sinus.
- Nasal irrigation is a potential route to administer drugs into the
sinus in unoperated CRS patients.
- The overall sinus distribution of nasal irrigation had significantly
more superiority than the nasal spray.
- This intervention brings the advantage of opportunely providing
anti-inflammatory medications into the sinus using a one-step approach
for initial CRS treatment.