Conclusion
Nasal irrigation is a potential route to administer drugs into the sinus in unoperated CRS
patients. Patients with phenotyping of moderate to high severity disease of sinuses and the CRSsNP might benefit from having drugs delivered into the sinus via nasal irrigation. However, the alternative technique is not superior to using nasal spray at the most challenging anatomical areas, i.e., the frontal and sphenoid sinuses.