Conclusion
As the most remarkable therapeutic property of celery is BP reduction, it was important to figure out the safety evaluation of celery in humans as herbal medicine. In this study, celery seed capsules (1.34g extract per day) were given to patients as drug supplements in a randomized, triple-blind, placebo-controlled, cross-over clinical trial. The results indicated that the celery seed capsule not only is safe for hypertensive patients but also caused a reduction in BP values, improved kidney and liver function, FBS, and lipid profile, which are statistically and clinically significant and were in normal ranges. However, no significant change was observed in blood cells and serum electrolytes. According to the promising results of this clinical trial, celery seed extract can be considered a safe supplement for hypertensive patients.