Acknowledgements:
Manna Semere Gebreyesus has submitted part of this work (based on data from pregnant patients) in her master’s thesis, in partial fulfilment of the requirements for the MPhil degree at the University of Cape Town, which was funded by South Africa’s National Research Foundation (NRF). This work has been presented as a poster at the 29th Population Approach Group Europe (PAGE) conference. An interim analysis including data from the PIE trial (only pregnant patients) was published as an abstract in CPT: Pharmacometrics & Systems Pharmacology, Volume 9, Issue S1, Pages: S9-S26 in November 2020.
The authors would like to acknowledge Professors Stephen Tong and Susan Walker from the department of Obstetrics and Gynaecology, University of Melbourne in Australia who are authors of the pre-clinical work that led to the PIE clinical study.