DISCUSSION
T-cell lymphoblastic lymphoma is a very rare form of non-Hodgkin
lymphoma, accounting for approximately 20% of LL.1,2It commonly occurs in young male adults, more than children or
elderly.2 T-LBL is frequently revealed by a
mediastinal mass or peripheral lymphadenopathy. Skin localizations of
all LBL are noted in fewer than 20% of affected
patients.3 Unlike B-cell LBL (B-LBL), skin involvement
concerns only a minority of patients with T-LBL, as well as lymph node
involvement. To our knowledge, only 15 cases of T-LBL with cutaneous
involvement have been reported in the literature.1,4,5Skin lesions mostly present as nodular lesions, located on the scalp,
the trunc and the limbs. Skin lesions in T-LBL usually present as
multiple nodules associated with multiple peripheral lymphadenopathy and
bone marrow invasion. Our patient is particular by the revealing
presentation of the lesions as CVG without other distant lesions. Only
four cases of T-LBL diagnosed by cutaneous involvement have been
reported so far.1
To our knowledge, secondary CVG revealing T-LBL has not been reported
previously.
Dermoscopic features of skin lésions are not specific for
LBL.6 However, they are comparable to that primary
cutaneous CD4+ small/medium T-cell lymphoproliferative disorders
presenting as short fine irregular or serpiginous vessels over
salmon-pink background. The authors correlate the presence of pinkish
background with atypical lymphocytic infiltrates related
angiogenesis.6
- Y.
Chiba, N.Hirase, K.Yamasaki, et al. Mediastinal T-cell Lymphoblastic
Lymphoma Diagnosed with a Skin Biopsy. Intern
Med. 2020;59(11):1463-1464.
- S.Khurana, M.Beltran, L.Jiang,
et al. Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report
and Literature Review. Case Rep Hematol, 2019;2019:3540487.
- Lee WJ, Moon HR, Won CH,et al. Precursor B- or T-lymphoblastic
lymphoma presentingwith cutaneous involvement: a series of 13 cases
including7 cases of cutaneous T-lymphoblastic lymphoma. J Am Acad
Dermatol 2014;70(2):318- 325.
- C. Nascimbenia, S. Chantepieb, C. Brugiere, et al. Localisations
cutanées d’un lymphomalymphoblastique T.Ann DermatolVenereol (2017).
- Montes-Torres A, Llamas-Velasco M, Capusan TM, et al. Cutaneous
involvement as the first manifestation of T lymphoblastic lymphoma and
review of the literature. J Cutan Pathol 2019;46(5): 372-375.
- M. Sławi_nska, M. Sokołowska-Wojdyło, B. Olszewska, et al.
Dermoscopic and trichoscopic features of primary cutaneous lymphomas
– systematic review. J Eur Acad Dermatol Venereol.2021 ;35(7) :
1470-1484.