Conclusions
In our real-world study, our results indicated that the CES1 polymorphism rs8192935 was associated with trough plasma concentrations of dabigatran. Carriers of the G allele had increased trough plasma concentrations of dabigatran compared to noncarriers. The ABCB1 polymorphisms rs4148738 and rs1045642 were associated with an increased risk for major bleeding events. These genetic associations could be useful for predicting the effect of dabigatran along with the bleeding risk for individuals, and further studies with larger sample sizes are needed to verify the findings.