Results
We identified 390 high-risk pedigrees with evidence for excess familial
aggregation (FSIR≥2.00 and P-value<0.05). FDRs, SDRs and TDRs
of affected parents had 1.14-fold (95% confidence interval [CI]:
1.04-1.26), 1.22-fold (95% CI: 1.11-1.33), and 1.15-fold (95% CI:
1.08-1.21) higher stillbirth odds compared to FDRs, SDRs and TDRs of
unaffected parents, respectively. Parental sex-specific analyses showed
male FDRs, SDRs and TDRs of affected fathers had 1.22-fold (95% CI:
1.02-1.47), 1.38-fold (95% CI: 1.17-1.62), 1.17-fold (95% CI:
1.05-1.30) higher stillbirth odds compared to those of unaffected
fathers, respectively. FDRs, SDRs and TDRs of affected mothers had
1.12-fold (95% CI: 0.98-1.28), 1.09-fold (95% CI: 0.96-1.24), and
1.15-fold (95% CI: 1.06-1.24) higher stillbirth odds compared with
those of unaffected mothers, respectively.