Secondary Analysis with MRSA excluded
Since MRSA had such a high occurrence rate within our population, we
reanalyzed our data without MRSA included. Without MRSA, Gram-negative
bacilli made up the majority of the MDROs. The most common resistant
organisms detected in tracheal aspirates excluding MRSA werePseudomonas aeruginosa (n=14, 26%) followed byAchromobacter xylosoxidans (n=13, 24%) and Klebsiella
pneumoniae (n=9, 17%) (Table E2). Overall, we had similar findings
with and without MRSA included in our analysis. We again found that
those who were MDRO-positive were more likely to have a greater number
of non-pulmonary admissions per year [OR=2.17, 95% CI (1.11-4.22),P= 0.02], more inpatient antibiotics use per year [OR=1.38,
95% CI (1.13-1.69), P= 0.002], and more IV and oral antibiotic
courses per year compared to MDRO-negative participants [OR=1.31, 95%
CI (1.09-1.57), P= 0.004] (Table E3). In contrast to the
analysis with MRSA included, in our analysis without MRSA we found that
participants who are MDRO-positive also had more pulmonary admissions
per year [OR=2.07, 95% CI (1.17-3.67), P= 0.01]. Using a
pair-wise comparison participants had more non-pulmonary admissions
(P= 0.04) and inpatient antibiotics (P= 0.02) prior to
having a MDRO compared to after MDRO positivity (Table E4). Unlike in
our full analysis we did not find that participants receive more
outpatient antibiotics following MDRO positivity (P= 0.20).